Particle Shape: A New Design Parameter for Passive Targeting In Splenotropic Drug Delivery

被引：80

作者：

Devarajan, Padma V. ^{[1
]}

Jindal, Anil B. ^{[1
]}

Patil, Rajesh R. ^{[1
]}

Mulla, Fernaz ^{[2
]}

Gaikwad, Rajiv V. ^{[2
]}

Samad, Abdul ^{[2
]}

机构：

[1] Inst Chem Technol, Dept Pharmaceut Sci & Technol, Bombay 400019, Maharashtra, India

[2] Bombay Vet Coll, Vet Nucl Med Ctr, Dept Med, Bombay 400012, Maharashtra, India

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 2010年 / 99卷 / 06期

关键词：

drug targeting; lipids; nanoparticles; particle size; scintigraphy; NANOPARTICLES; CELLS;

D O I：

10.1002/jps.22052

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The role of particle size and surface modification on biodistribution of nanocarriers is widely reported. We report for the first time the role of nanoparticle shape on biodistribution. Our study demonstrates that irregular shaped polymer lipid nanoparticles (LIPOMER) evade kupffer cells and localize in the spleen. We also demonstrate the macrophage-evading characteristic of the irregular-shaped LIPOMER. Our results suggest particle shape as an important tool for passive targeting of nanocarriers in splenotropic drug delivery. (C) 2010 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:2576-2581, 2010

引用

页码：2576 / 2581

页数：6

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