Particle Shape: A New Design Parameter for Passive Targeting In Splenotropic Drug Delivery

被引：79

作者：

Devarajan, Padma V. ^{[1
]}

Jindal, Anil B. ^{[1
]}

Patil, Rajesh R. ^{[1
]}

Mulla, Fernaz ^{[2
]}

Gaikwad, Rajiv V. ^{[2
]}

Samad, Abdul ^{[2
]}

机构：

[1] Inst Chem Technol, Dept Pharmaceut Sci & Technol, Bombay 400019, Maharashtra, India

[2] Bombay Vet Coll, Vet Nucl Med Ctr, Dept Med, Bombay 400012, Maharashtra, India

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 2010年 / 99卷 / 06期

关键词：

drug targeting; lipids; nanoparticles; particle size; scintigraphy; NANOPARTICLES; CELLS;

D O I：

10.1002/jps.22052

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The role of particle size and surface modification on biodistribution of nanocarriers is widely reported. We report for the first time the role of nanoparticle shape on biodistribution. Our study demonstrates that irregular shaped polymer lipid nanoparticles (LIPOMER) evade kupffer cells and localize in the spleen. We also demonstrate the macrophage-evading characteristic of the irregular-shaped LIPOMER. Our results suggest particle shape as an important tool for passive targeting of nanocarriers in splenotropic drug delivery. (C) 2010 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:2576-2581, 2010

引用

页码：2576 / 2581

页数：6

共 18 条

[1] THE USE OF GLYCOLIPIDS AND HYDROPHILIC POLYMERS IN AVOIDING RAPID UPTAKE OF LIPOSOMES BY THE MONONUCLEAR PHAGOCYTE SYSTEM
ALLEN, TM
[J]. ADVANCED DRUG DELIVERY REVIEWS, 1994, 13 (03) : 285 - 309
[2] Preparation, characterization and biodistribution of ultrafine chitosan nanoparticles
Banerjee, T
Mitra, S
Singh, AK
Sharma, RK
Maitra, A
[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2002, 243 (1-2) : 93 - 105
[3] Role of target geometry in phagocytosis
Champion, JA
Mitragotri, S
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (13) : 4930 - 4934
[4] Shape Induced Inhibition of Phagocytosis of Polymer Particles
Champion, Julie A.
Mitragotri, Samir
[J]. PHARMACEUTICAL RESEARCH, 2009, 26 (01) : 244 - 249
[5] Highly restricted spread of HIV-1 and multiply infected cells within splenic germinal centers
Gratton, S
Cheynier, R
Dumaurier, MJ
Oksenhendler, E
Wain-Hobson, S
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (26) : 14566 - 14571
[6] Joshi S, 2007, INTERNET J MED UPDAT, V2, P38
[7] TISSUE TROPISM OF DIFFERENT TRYPANOSOMA-CRUZI STRAINS
MELO, RC
BRENER, Z
[J]. JOURNAL OF PARASITOLOGY, 1978, 64 (03) : 475 - 482
[8] TISSUE SPECIFIC OPSONINS FOR PHAGOCYTIC-CELLS AND THEIR DIFFERENT AFFINITY FOR CHOLESTEROL-RICH LIPOSOMES
MOGHIMI, SM
PATEL, HM
[J]. FEBS LETTERS, 1988, 233 (01): : 143 - 147
[9] NON-PHAGOCYTIC UPTAKE OF INTRAVENOUSLY INJECTED MICROSPHERES IN RAT SPLEEN - INFLUENCE OF PARTICLE-SIZE AND HYDROPHILIC COATING
MOGHIMI, SM
PORTER, CJH
MUIR, IS
ILLUM, L
DAVIS, SS
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 177 (02) : 861 - 866
[10] Moghimi SM, 2001, PHARMACOL REV, V53, P283

← 1 2 →