Effect of medical and surgical weight loss on endothelial vasomotor function in obese patients

被引：396

作者：

Gokce, N

Vita, JA

McDonnell, M

Forse, AR

Istfan, N

Stoeckl, M

Lipinska, I

Keaney, JF

Apovian, CM

机构：

[1] Boston Univ, Med Ctr, Sch Med, Evans Dept Med,Cardiol & Endocrinol Sect, Boston, MA 02118 USA

[2] Boston Univ, Med Ctr, Sch Med, Dept Surg,Gastrointestinal Sect, Boston, MA 02118 USA

[3] Boston Univ, Med Ctr, Sch Med, Whitaker Cardiovasc Inst, Boston, MA 02118 USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2005年 / 95卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.amjcard.2004.09.016

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We prospectively examined brachial artery endothelial function using vascular ultrasound in 41 obese subjects treated with medical or surgical (gastric bypass) weight loss interventions. Surgical intervention produced greater weight loss and more pronounced improvement in enclothelial function than medical treatment alone. Improved enclothelial function with weight loss correlated strongly with fasting glucose but not with alteration in blood pressure, lipids, degree of weight loss, or plasma resistin concentrations. These data demonstrate that weight loss in markedly obese patients improves enclothelial function and glycemic control that may represent important mechanisms of the cardiovascular benefit associated with weight reduction. (C) 2005 by Excerpta Medica Inc.

引用

页码：266 / 268

页数：3

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