Long-term function of parathyroid subcutaneous autoimplantation after presumed total parathyroidectomy in the treatment of secondary hyperparathyroidism. A clinical retrospective study

被引:24
作者
Conzo, G. [1 ]
Della Pietra, C. [1 ]
Tartaglia, E. [1 ]
Gambardella, C. [1 ]
Mauriello, C. [1 ]
Palazzo, A. [1 ]
Santini, L. [1 ]
Fei, L. [2 ]
Rossetti, G. [2 ]
Docimo, G. [1 ]
Perna, A. [3 ]
机构
[1] Univ Naples 2, Div Gen Surg 7, Dept Anaesthesiol Surg & Emergency Sci, I-80131 Naples, Italy
[2] Univ Naples 2, Unit Gen Surg & Digest Physiopathol F Magrassi A, Dept Clin & Expt Med & Surg, I-80131 Naples, Italy
[3] Univ Naples 2, Div Nephrol 1, Dept Cardiothorac & Resp Sci, I-80131 Naples, Italy
关键词
Autotransplantation; Subcutaneous implantation; Muscular implantation; Chronic kidney disease; Parathyroidectomy; Secondary hyperparathyroidism; RENAL HYPERPARATHYROIDISM; SURGICAL-TREATMENT; TOTAL THYROIDECTOMY; HORMONE ASSAY; AUTOTRANSPLANTATION; SURVIVAL; TRANSPLANTATION; DIALYSIS; GLANDS; IMPACT;
D O I
10.1016/j.ijsu.2014.05.019
中图分类号
R61 [外科手术学];
学科分类号
摘要
Introduction: Parathyroidectomy (PTx) is recommended in patients affected by secondary hyperparathyroidism (2HPT) of chronic kidney disease-mineral bone disorders (CKD-MBD), resistant to medical treatment. Analyzing total parathyroidectomy with muscular or subcutaneous autoimplantation (TPai) outcomes in hemodialysis (HD) 2HPT patients, and monitoring intact parathyroid hormone (iPTH) levels, we evaluated long-term functional results of subcutaneous parathyroid glandular tissue autoimplantation. Methods: 40 HD 2HPT patients, resistant to medical treatment, and awaiting for renal transplantation, underwent total parathyroidectomy with subcutaneous autoimplantation of 9-12 fragments of not nodular hyperplasia parathyroid tissue in notdominant forearm. iPTH were analyzed 24 h, and 3-6-12-24 months after surgery. The 1.08-6.99 pmol/L range was taken as reference of normal iPTH level based on which eu- (1.08-6.99), hypo-(< 1.08), aparathyroidism (0) and persistence or relapse (>6.99) of disease were determined. Results: In every case PTai determined an extraordinary improvement of quality of life, associated with a notable reduction of iPTH serum level. Immediate normalization of iPTH was achieved in 50% of cases; hypoparathyroidism in 25% of cases and persistence of disease in 25% were observed. Long term follow-up showed a reduction of hypoparathyroidism and an increase of relapse rate up to 20%. Grafting resection was never performed. Discussion: Subcutaneous autotrasplantation is a very simple and fast surgical technique. Nevertheless, similar success and recurrence rates were reported following muscular or subcutaneous grafting, as confirmed in our experience. Conclusions: Subcutaneous grafting was effective as muscular implantation, with comparable functional results, but avoiding its potential complications. (C) 2014 Published by Elsevier Ltd on behalf of Surgical Associates Ltd.
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收藏
页码:S165 / S169
页数:5
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