Gap junctions promote synchronous activities in a network of inhibitory interneurons

被引：14

作者：

Di Garbo, A ^{[1
]}

Panarese, A ^{[1
]}

Chillemi, S ^{[1
]}

机构：

[1] CNR, Ist Biofis, Sez Pisa, I-56124 Pisa, Italy

来源：

BIOSYSTEMS | 2005年 / 79卷 / 1-3期

关键词：

synchronization; interneuron; inhibitory; excitatory; gap junctions;

D O I：

10.1016/j.biosystems.2004.09.004

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

By using a single compartment biophysical model of a fast spiking interneuron the synchronization properties of a pair of cells, coupled by electrical and inhibitory synapses, are investigated. The inhibitory and excitatory synaptic couplings are modeled in order to reproduce the experimental time course of the corresponding currents. It is shown that increasing the conductance value of the electrical synapses enhances the synchronization between the spike trains of the two cells. Moreover, increasing either the decay time constant of the inhibitory current or the firing frequency of the cells favours the emergence of synchronous discharges. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

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页码：91 / 99

页数：9

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