A new function for old drugs

被引:8
作者
Das, Riku [1 ]
Plow, Edward F. [1 ]
机构
[1] Cleveland Clin, Joseph J Jacobs Ctr Thrombosis & Vasc Biol, Dept Mol Cardiol, Lerner Res Inst, Cleveland, OH 44106 USA
关键词
plasminogen; plasminogen receptor; macrophage; L-type Ca2+ channel; amlodipine; verapamil; inflammation; MURINE MODEL; PLASMINOGEN; MONOCYTES; ACTIVATION; EXPRESSION;
D O I
10.4161/cc.9.4.11016
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
引用
收藏
页码:638 / 639
页数:2
相关论文
共 11 条
  • [1] The serine protease plasmin triggers expression of MCP-1 and CD40 in human primary monocytes via activation of p38 MAPK and Janus kinase (JAK)/STAT signaling pathways
    Burysek, L
    Syrovets, T
    Simmet, T
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (36) : 33509 - 33517
  • [2] Cardioprotective effects of verapamil on myocardial structure and function in a murine model of chronic Trypanosoma cruzi infection (Brazil Strain):: an echocardiographic study
    Chandra, M
    Shirani, J
    Shtutin, V
    Weiss, LM
    Factor, SM
    Petkova, SB
    Rojkind, M
    Dominguez-Rosales, JA
    Jelicks, LA
    Morris, SA
    Wittner, M
    Tanowitz, HB
    [J]. INTERNATIONAL JOURNAL FOR PARASITOLOGY, 2002, 32 (02) : 207 - 215
  • [3] Histone H2B as a functionally important plasminogen receptor on macrophages
    Das, Riku
    Burke, Tim
    Plow, Edward F.
    [J]. BLOOD, 2007, 110 (10) : 3763 - 3772
  • [4] L-Type Calcium Channel Blockers Exert an Antiinflammatory Effect by Suppressing Expression of Plasminogen Receptors on Macrophages
    Das, Riku
    Burke, Tim
    Van Wagoner, David R.
    Plow, Edward F.
    [J]. CIRCULATION RESEARCH, 2009, 105 (02) : 167 - U137
  • [5] Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice
    Gong, Yanqing
    Hart, Erika
    Shchurin, Aleksey
    Hoover-Plow, Jane
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (09) : 3012 - 3024
  • [6] Novel anti-inflammatory actions of amlodipine in a rat model of arteriosclerosis induced by long-term inhibition of nitric oxide synthesis
    Kataoka, C
    Egashira, K
    Ishibashi, M
    Inoue, S
    Ni, WH
    Hiasa, K
    Kitamoto, S
    Usui, M
    Takeshita, A
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2004, 286 (02): : H768 - H774
  • [7] The plasminogen activator/plasmin system is essential for development of the joint inflammatory phase of collagen type II-induced arthritis
    Li, JN
    Ny, A
    Leonardsson, G
    Nandakumar, KS
    Holmdahl, R
    Ny, T
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2005, 166 (03) : 783 - 792
  • [8] MATSUSHIMA K, 1986, J IMMUNOL, V136, P2883
  • [9] The functions of plasminogen in cardiovascular disease
    Plow, EF
    Hoover-Plow, J
    [J]. TRENDS IN CARDIOVASCULAR MEDICINE, 2004, 14 (05) : 180 - 186
  • [10] Plasminogen is an important regulator in the pathogenesis of a murine model of asthma
    Swaisgood, Carmen M.
    Aronica, Mark A.
    Swaidani, Shadi
    Plow, Edward F.
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2007, 176 (04) : 333 - 342