Identification of photoproducts of folic acid and its degradation pathways in aqueous solution

被引：63

作者：

Akhtar, MJ

Khan, MA

Ahmad, I

机构：

[1] GlaxoSmithKline Pakistan Ltd, Res & Dev Labs, Karachi, Pakistan

[2] Univ Karachi, Dept Chem, Organ Sect, Karachi 75270, Pakistan

[3] Dubai Pharm Coll, Dubai, U Arab Emirates

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2003年 / 31卷 / 03期

关键词：

folic acid; pterin-6-carboxylic acid; p-aminobenzoyl-L-glutamic acid; photolysis; photodegradation pathways;

D O I：

10.1016/S0731-7085(02)00724-0

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The UV irradiated aqueous solutions of folic acid at pH 2-10 degrade to give pterin-6-carboxylic acid and p-aminobenzoyl-L-glutamic acid under aerobic conditions. These photoproducts have been identified by TLC, HPLC and Spectrophotometric techniques. A reaction scheme for the photodegradation pathways of folic acid leading to the formation of the photoproducts in acid and alkaline media has been proposed which involves the participation of an enamine intermediate. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：579 / 588

页数：10

共 18 条

[1]

Akhtar MJ, 2000, J PHARMACEUT BIOMED, V23, P1039

[2] High performance liquid chromatographic determination of folic acid and its photodegradation products in the presence of riboflavin [J].