An antioxidant tetrapeptide UPF1 in rats has a neuroprotective effect in transient global brain ischemia

被引：12
作者：
Poder, P
Zilmer, M
Starkopf, J
Kals, J
Talonpoika, A
Pulges, A
Langel, Ü
Kullisaar, T
Viirlaid, S
Mahlapuu, R
Zarkovski, A
Arend, A
Soomets, U
机构：
[1] Univ Tartu, European Ctr Mol & Clin Med, Dept Biochem, EE-50411 Tartu, Estonia
[2] Univ Tartu, European Ctr Mol & Clin Med, Clin Cardiovasc & Thorac Surg, EE-50411 Tartu, Estonia
[3] Univ Tartu, Clin Anaesthesiol & Intens Care, EE-50411 Tartu, Estonia
[4] Stockholm Univ, Dept Neurochem & Neurotoxicol, S-10691 Stockholm, Sweden
[5] Univ Tartu, Dept Pharmacol, EE-50090 Tartu, Estonia
[6] Univ Tartu, Dept Histol, EE-50090 Tartu, Estonia
来源：
NEUROSCIENCE LETTERS | 2004年 / 370卷 / 01期
关键词：
four-vessel occlusion model; global brain ischemia; glutathione; hippocampus; antioxidant;
D O I：
10.1016/j.neulet.2004.07.063
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Different glutathione analogues have potential to maintain or increase tissue glutathione level and to scavenge the reactive oxygen species. We designed and synthesized a novel non-toxic glutathione analogue, named UPF1, which possessed 60-fold higher hydroxyl radical scavenger efficiency in vitro. compared with glutathione itself, and investigated the effects of UPF1 on a four-vessel occlusion model of rats. The UPF1 was administered via the jugular vein in two separate experiments at two time points: 20 min before global brain ischemia and immediately before reperfusion. In both cases the number of pyramidal cells surviving in the subfield of CA 1 at the dorsal hippocampus in the UPF1-treated groups of rats was twice as high as in the vehicle group. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：45 / 50
页数：6
相关论文
共 22 条
[1]   Glutathione monoethylester prevents mitochondrial glutathione depletion during focal cerebral ischemia [J].
Anderson, MF ;
Nilsson, M ;
Sims, NR .
NEUROCHEMISTRY INTERNATIONAL, 2004, 44 (03) :153-159
[2]   Neuroprotective effect of law dose riluzole in gerbil model of transient global ischemia [J].
Bae, HJ ;
Lee, YS ;
Kang, DW ;
Gu, JS ;
Yoon, BW ;
Roh, JK .
NEUROSCIENCE LETTERS, 2000, 294 (01) :29-32
[3]  
BARRETO JC, 1995, LIFE SCI, V56, P89
[4]   Time course of oxidative damage in different brain regions following transient cerebral ischemia in gerbils [J].
Candelario-Jalil, E ;
Mhadu, NH ;
Al-Dalain, SM ;
Martínez, G ;
León, OS .
NEUROSCIENCE RESEARCH, 2001, 41 (03) :233-241
[5]   OXYGEN FREE-RADICAL INVOLVEMENT IN ISCHEMIA AND REPERFUSION INJURY TO BRAIN [J].
CAO, W ;
CARNEY, JM ;
DUCHON, A ;
FLOYD, RA ;
CHEVION, M .
NEUROSCIENCE LETTERS, 1988, 88 (02) :233-238
[6]   BN 80933, a dual inhibitor of neuronal nitric oxide synthase and lipid peroxidation:: A promising neuroprotective strategy [J].
Chabrier, PE ;
Auguet, M ;
Spinnewyn, B ;
Auvin, S ;
Cornet, S ;
Demerlé-Pallardy, C ;
Guilmard-Favre, C ;
Marin, JG ;
Pignol, B ;
Gillard-Roubert, V ;
Roussillot-Charnet, C ;
Schulz, J ;
Viossat, I ;
Bigg, D ;
Moncada, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (19) :10824-10829
[7]   Role of oxidants in ischemic brain damage [J].
Chan, PH .
STROKE, 1996, 27 (06) :1124-1129
[8]   Transient global brain hypoxia-ischemia in adult rats: Neuronal damage, glial proliferation, and alterations in inositol phospholipid hydrolysis [J].
Fortuna, S ;
Pestalozza, S ;
Lorenzini, P ;
Bisso, GM ;
Morelli, L ;
Michalek, H .
NEUROCHEMISTRY INTERNATIONAL, 1997, 31 (04) :563-569
[9]   SELECTIVE RELEASE OF GLUTAMATE FROM CEREBELLAR GRANULE CELLS DIFFERENTIATING IN CULTURE [J].
GALLO, V ;
CIOTTI, MT ;
COLETTI, A ;
ALOISI, F ;
LEVI, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (24) :7919-7923
[10]   Hippocampal cell loss in transient global cerebral ischemia in rats:: A critical assessment [J].
Herguido, MJ ;
Carceller, F ;
Roda, JM ;
Avendaño, C .
NEUROSCIENCE, 1999, 93 (01) :71-80
123