Vitamin K, Vascular Calcification, and Chronic Kidney Disease: Current Evidence and Unanswered Questions

被引：21

作者：

Shea, M. Kyle ^{[1
]}

Booth, Sarah L. ^{[1
]}

机构：

[1] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA

来源：

CURRENT DEVELOPMENTS IN NUTRITION | 2019年 / 3卷 / 09期

关键词：

vitamin K; phylloquinone; chronic kidney disease; coronary artery calcium; cardiovascular disease; MATRIX GLA-PROTEIN; CORONARY-ARTERY CALCIUM; ALL-CAUSE MORTALITY; CARDIOVASCULAR-DISEASE; FUNCTION DECLINE; HEART-DISEASE; WARFARIN USE; RISK-FACTOR; STIFFNESS; PROGRESSION;

D O I：

10.1093/cdn/nzz077

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

More than 15% of the US population is currently >65 y old. As populations age there is a concomitant increase in age-related chronic diseases. One such disease is chronic kidney disease (CKD), which becomes more prevalent with age, especially over age 70 y. Individuals with CKD are at increased risk of cardiovascular disease, in part because arterial calcification increases as kidney function declines. Vitamin K is a shortfall nutrient among older adults that has been implicated in arterial calcification. Evidence suggests CKD patients have low vitamin K status, but data are equivocal because the biomarkers of vitamin K status can be influenced by CKD. Animal studies provide more compelling data on the underlying role of vitamin K in arterial calcification associated with CKD. The purpose of this review is to evaluate the strengths and limitations of the available evidence regarding the role of vitamin K in CKD.

引用

页数：8

共 85 条

[1]

[Anonymous], 2001, DIET REF INT VIT A V

[2] High Dephosphorylated-Uncarboxylated MGP in Hemodialysis patients: risk factors and response to vitamin K2, A pre-post intervention clinical trial [J].

Aoun, Mabel ;

Makki, Maha ;

Azar, Hiba ;

Matta, Hiam ;

Chelala, Dania Nehme .

BMC NEPHROLOGY, 2017, 18

[3] DEVELOPMENTAL EXPRESSION AND HORMONAL-REGULATION OF THE RAT MATRIX GLA PROTEIN (MGP) GENE IN CHONDROGENESIS AND OSTEOGENESIS [J].

BARONE, LM ;

OWEN, TA ;

TASSINARI, MS ;

BORTELL, R ;

STEIN, GS ;

LIAN, JB .

JOURNAL OF CELLULAR BIOCHEMISTRY, 1991, 46 (04) :351-365

[4] Carotid arterial stiffness as a predictor of cardiovascular and all-cause mortality in end-stage renal disease [J].

Blacher, J ;

Pannier, B ;

Guerin, AP ;

Marchais, SJ ;

Safar, ME ;

London, GM .

HYPERTENSION, 1998, 32 (03) :570-574

[5]

Bloom DE, 2016, HBK ECON, P3, DOI 10.1016/bs.hespa.2016.06.002

[6] Dietary phylloquinone depletion and repletion in older women [J].

Booth, SL ;

Martini, L ;

Peterson, JW ;

Saltzman, E ;

Dallal, GE ;

Wood, RJ .

JOURNAL OF NUTRITION, 2003, 133 (08) :2565-2569

[7] Progression of Coronary Calcium and Incident Coronary Heart Disease Events MESA (Multi-Ethnic Study of Atherosclerosis) [J].

Budoff, Matthew J. ;

Young, Rebekah ;

Lopez, Victor A. ;

Kronmal, Richard A. ;

Nasir, Khurram ;

Blumenthal, Roger S. ;

Detrano, Robert C. ;

Bild, Diane E. ;

Guerci, Alan D. ;

Liu, Kiang ;

Shea, Steven ;

Szklo, Moyses ;

Post, Wendy ;

Lima, Joao ;

Bertoni, Alain ;

Wong, Nathan D. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2013, 61 (12) :1231-1239

[8] Relationship of Estimated GFR and Coronary Artery Calcification in the CRIC (Chronic Renal Insufficiency Cohort) Study [J].

Budoff, Matthew J. ;

Rader, Daniel J. ;

Reilly, Muredach P. ;

Mohler, Emile R., III ;

Lash, Jim ;

Yang, Wei ;

Rosen, Leigh ;

Glenn, Melanie ;

Teal, Valerie ;

Feldman, Harold I. .

AMERICAN JOURNAL OF KIDNEY DISEASES, 2011, 58 (04) :519-526

[9] Progression of Coronary Artery Calcium Predicts All-Cause Mortality [J].

Budoff, Matthew J. ;

Hokanson, John E. ;

Nasir, Khurram ;

Shaw, Leslee J. ;

Kinney, Gregory L. ;

Chow, David ;

DeMoss, Daniel ;

Nuguri, Vivek ;

Nabavi, Vahid ;

Ratakonda, Raghu ;

Berman, Daniel S. ;

Raggi, Paolo .

JACC-CARDIOVASCULAR IMAGING, 2010, 3 (12) :1229-1236

[10] Advances in Geroscience: Impact on Healthspan and Chronic Disease [J].

Burch, John B. ;

Augustine, Alison Deckhut ;

Frieden, Leslie A. ;

Hadley, Evan ;

Howcroft, T. Kevin ;

Johnson, Ron ;

Khalsa, Partap S. ;

Kohanski, Ronald A. ;

Li, Xiao Ling ;

Macchiarini, Francesca ;

Niederehe, George ;

Oh, Young S. ;

Pawlyk, Aaron C. ;

Rodriguez, Henry ;

Rowland, Julia H. ;

Shen, Grace L. ;

Sierra, Felipe ;

Wise, Bradley C. .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2014, 69 :S1-S3

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