Analysis of the Smad2 gene in hematological malignancies

被引：10

作者：

Ikezoe, T ^{[1
]}

Takeuchi, S ^{[1
]}

Kamioka, M ^{[1
]}

Daibata, M ^{[1
]}

Kubonishi, I ^{[1
]}

Taguchi, H ^{[1
]}

Miyoshi, I ^{[1
]}

机构：

[1] Kochi Med Sch, Dept Internal Med, Nanko Ku, Kochi 783, Japan

来源：

LEUKEMIA | 1998年 / 12卷 / 01期

关键词：

Smad2; TGF-beta; 18q21; tumor suppressor gene; hematological malignancies;

D O I：

10.1038/sj.leu.2400888

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A total of 34 leukemia and lymphoma samples (17 clinical samples and 17 cell lines) were analyzed for mutations of the Smad2 gene by reverse transcriptase-polymerase chain reaction single strand conformation polymorphism (RT-PCR-SSCP) analysis. Nine of Phe 34 samples had 18q chromosomal abnormalities. No shifted bands were detected in any of the hematological malignancies, Our results suggest that resistance Po cell growth inhibitory effects of TGF-beta in hematological malignancies is not due to alterations of the Smad2 gene.

引用

页码：94 / 95

页数：2

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