Metal-free, base catalyzed oxidative amination and denitration reaction: Regioselective synthesis of 3-arylimidazo[1,2-a]pyridines

被引：12

作者：

Devi, Elango Sankari ^{[1
]}

Alanthadka, Anitha ^{[1
]}

Nagarajan, Subbiah ^{[1
,2
]}

Sridharan, Vellaisamy ^{[1
,3
]}

Maheswari, Chockalingam Uma ^{[1
]}

机构：

[1] SASTRA Deemed Univ, Sch Chem & Biotechnol, Dept Chem, Organ Synth Grp, Thanjavur 613401, India

[2] Natl Inst Technol, Dept Chem, Warangal 506004, Telangana, India

[3] Cent Univ Jammu, Dept Chem & Chem Sci, Sainik Colony Sect E Extens, Temporary Acad Block, Jammu 180011, India

来源：

TETRAHEDRON LETTERS | 2018年 / 59卷 / 38期

关键词：

Imidazo[1,2-a]pyridines; beta-Nitrostyrenes; 2-Aminopyridines; Oxidation; Base catalysis; ONE-POT SYNTHESIS; IMIDAZOPYRIDINE; INHIBITORS; OLPRINONE;

D O I：

10.1016/j.tetlet.2018.08.024

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A metal-free, regioselective strategy for the synthesis of 3-arylimidazo[1,2-a]pyridines from beta-nitrostyrenes and 2-aminopyridines using triethylamine as the catalyst and H2O2 (30% aq.) as the oxidant is reported. The use of an inexpensive base and facile reaction conditions make this strategy a practical alternative for the synthesis of 3-arylimidazo[1,2-a]pyridines. (C) 2018 Published by Elsevier Ltd.

引用

页码：3485 / 3489

页数：5

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