Mucobilia: current aspects in the management of a rare cause of malignant biliary obstruction

被引:5
作者
Brown, Melanie-Antonietta [1 ]
Sakpal, Sujit Vijay [1 ]
Chamberlain, Ronald Scott [1 ,2 ]
机构
[1] St Barnabas Hosp, Dept Surg, Livingston, NJ 07039 USA
[2] Univ Med & Dent New Jersey, Dept Surg, Newark, NJ 07103 USA
关键词
Mucin; Mucin-producing biliary tumor; Mucobilia; Obstructive jaundice; PAPILLARY MUCINOUS NEOPLASM; BILE-DUCTS; CYSTADENOCARCINOMA; CHOLANGIOCARCINOMA; DIAGNOSIS; TUMOR; LIVER; HEPATOLITHIASIS; PAPILLOMATOSIS; PANCREAS;
D O I
10.1007/s00534-009-0150-2
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Mucobilia is a rare pathologic condition characterized by the abnormal secretion and accumulation of abundant mucus within the biliary tree. It is usually seen in association with mucin-producing hepatobiliary and pancreatic tumors. Neoplastic transformation of these tumors can range from low-grade dysplasia to invasive adenocarcinoma. Mucobilia usually presents with signs and symptoms of biliary obstruction, which may span from jaundice to cholangitis with progression to septic complications in severe cases. Occurrence of hepatolithiasis has also been attributed to mucobilia, which raises the concern of an increased risk for the development of cholangiocarcinoma. Precise radiological evaluation and detailed histopathological tissue diagnosis followed by execution of appropriate surgical therapy is vital in the integrated management of mucin-producing biliary neoplasms. This review will address the etiologies and symptomatology of mucobilia as well as discuss current aspects in the management of mucobilia and its causative etiologies.
引用
收藏
页码:205 / 210
页数:6
相关论文
共 35 条
[1]   Intraductal oncocytic papillary neoplasms of the pancreas [J].
Adsay, NV ;
Adair, CF ;
Heffess, CS ;
Klimstra, DS .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1996, 20 (08) :980-994
[2]   INTERMITTENT JAUNDICE BY TUMOR EMBOLI FROM INTRAHEPATIC CHOLANGIOCARCINOMA [J].
CAPIZZI, PJ ;
ROSEN, CB ;
NAGORNEY, DM .
GASTROENTEROLOGY, 1992, 103 (05) :1669-1673
[3]  
CAROLI J, 1959, Rev Med Chir Mal Foie, V34, P191
[4]  
Chamberlain R S, 2000, HPB Surg, V11, P345, DOI 10.1155/2000/48426
[5]  
CHEN MF, 1993, CANCER, V71, P2461, DOI 10.1002/1097-0142(19930415)71:8<2461::AID-CNCR2820710806>3.0.CO
[6]  
2-7
[7]   Mucobilia: The clinical spectrum, diagnosis and treatment [J].
Chen, MF .
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 1998, 13 (11) :1084-1090
[8]  
GOINARD P, 1960, Mem Acad Chir (Paris), V86, P849
[9]   MUCOBILIA - AN UNUSUAL CAUSE OF JAUNDICE [J].
HADJIS, NS ;
SLATER, RNS ;
BLUMGART, LH .
BRITISH JOURNAL OF SURGERY, 1987, 74 (01) :48-49
[10]  
IEMOTO Y, 1981, CANCER-AM CANCER SOC, V48, P1664, DOI 10.1002/1097-0142(19811001)48:7<1664::AID-CNCR2820480731>3.0.CO