A pH-, thermo-, and glucose-, triple-responsive hydrogels: Synthesis and controlled drug delivery

被引：83

作者：

Wang, Lu

Liu, Mingzhu ^{[1
]}

Gao, Chunmei

Ma, Liwei

Cui, Dapeng

机构：

[1] Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

REACTIVE & FUNCTIONAL POLYMERS | 2010年 / 70卷 / 03期

关键词：

Hydrogels; Multi-responsive; Controlled drug release; 3-Acrylamidephenylboronic acid; (2-Dimethylamino) ethyl methacrylate; TRANSFER RADICAL POLYMERIZATION; IMMOBILIZATION; TEMPERATURE; GLYCOSURIA; COPOLYMER; TRANSPORT; POLYMERS; RELEASE; ACID); GELS;

D O I：

10.1016/j.reactfunctpolym.2009.11.007

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In this work, a series of hydrogels were prepared by copolymerization of (2-dimethylamino) ethyl methacrylate (DMAEMA) and 3-acrylamidephenylboronic acid (AAPBA). The structure of the resultant hydrogels was studied by Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM). The experimental results from swelling studies revealed that the hydrogels displayed definite glucose sensitivity under physiological conditions, as well as sharp changes in the mesh size of their network as a function of the pH and temperature of the swelling media. Bovine serum albumin (BSA) was selected as a model compound when examining protein release from hydrogels. The results suggested that the temperature, pH and glucose concentration of buffer solutions greatly influenced release profiles. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：159 / 167

页数：9

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