The role of bacterial pathogens in cancer

被引：97
作者：
Vogelmann, Roger
Amieva, Manuel R.
机构：
[1] Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA
[2] Tech Univ Munich, Klinikum Rechts Isar, Med Klin 2, D-81675 Munich, Germany
来源：
CURRENT OPINION IN MICROBIOLOGY | 2007年 / 10卷 / 01期
关键词：
D O I：
10.1016/j.mib.2006.12.004
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The association of Helicobacter pylori with gastric cancer is the best-studied relationship between a bacterial infection and cancer. Other bacterial pathogens in humans and rodents are now being recognized as potentially having a direct role in carcinogenesis. Thus, it might be possible to understand the pathogenesis and prevention of certain cancers by studying the bacterial infections associated with them, and their effects on the host. However, the mechanisms by which bacteria contribute to cancer formation are complex, and recent investigations show that they involve the interplay between chronic inflammation, direct microbial effects on host cell physiology and, ultimately, changes in tissue stem cell physiology and, ultimately, changes in tissue stem cell homeostasis.
引用
收藏
页码：76 / 81
页数：6
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