Vitamin B6 improves the immunogenicity of cisplatin-induced cell death

被引：15

作者：

Aranda, Fernando ^{[1
,2
,3
,4
]}

Bloy, Norma ^{[1
,2
,3
,4
]}

Galluzzi, Lorenzo ^{[1
,2
,3
,4
]}

Kroemer, Guido ^{[1
,2
,3
,5
,6
,7
]}

Senovilla, Laura ^{[1
,3
,4
,5
,6
,8
]}

机构：

[1] Ctr Rech Cordeliers, Equipe Labelisee Ligue Natl Canc 11, Paris, France

[2] Univ Paris 05, Sorbonne Paris Cite, Paris, France

[3] INSERM U1138, Paris, France

[4] Gustave Roussy Comprehens Canc Ctr, Villejuif, France

[5] Gustave Roussy Comprehens Canc Ctr, Metabol Platform, Villejuif, France

[6] Gustave Roussy Comprehens Canc Ctr, Cell Biol Platforms, Villejuif, France

[7] Hop Europeen Georges Pompidou, AP HP, Pole Biol, Paris, France

[8] INSERM U1015, Villejuif, France

来源：

ONCOIMMUNOLOGY | 2014年 / 3卷 / 09期

关键词：

apoptosis; ATP; autophagy; calreticulin; endoplasmic reticulum stress; HMGB1; PDXK; METABOLISM; CANCER;

D O I：

10.4161/21624011.2014.955685

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have recently demonstrated that pyridoxine, a precursor of vitamin B6, increases the immunogenicity of non-small cell lung carcinoma (NSCLC) cells succumbing to cisplatin (cis-diamminedichloroplatinum(II), CDDP). Accordingly, pyridoxine promoted the antineoplastic activity of CDDP in NSCLC-bearing mice only in the presence of an intact immune system. These findings may have implications for the development of novel strategies to circumvent CDDP resistance.

引用

页数：3

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