Lipid peroxidation and antioxidant enzyme status of adult males with skeletal fluorosis in Andhra Pradesh, India

被引：0
作者：
Kalyanalakshmi, P.
Vijayabhaskar, M. [1 ]
Naidu, M. Dhananjaya
机构：
[1] Mamatha Med Coll, Dept Biochem, Khammam 517002, Andhra Pradesh, India
[2] Sri Venkateswara Univ, Dept Biotechnol, Tirupati 517502, Andhra Pradesh, India
来源：
FLUORIDE | 2007年 / 40卷 / 01期
关键词：
Andhra Pradesh; India; antioxidant status; catalase; glutathione-S-transferase; lipid peroxidation; malondialdehyde; skeletal fluorosis;
D O I：
暂无
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Blood samples from 24 adult males, age 25 to 40, with endemic skeletal fluorosis, living in the Vaillapally village of the Nalgonda district, Andhra Pradesh, India, were examined and compared with samples from 15 matched controls for their antioxidant enzyme activity and lipid peroxidation. Elevated malondialdehyde (MDA) levels indicated an increase in lipid peroxidation products, and decreased activity levels of catalase (CAT) and glutathione-S-transferase (GST) reflected significant alterations in their antioxidant status. These results, in agreement with recent findings by others, demonstrate that chronic fluoride intoxication in adult males elicits increased lipid peroxidation associated with a significant decrease in the activities of CAT and GST.
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页码：42 / 45
页数：4
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