Breast cancer brain metastases: evidence for neuronal-like adaptation in a 'breast-to-brain' transition?

被引：17

作者：

Van Swearingen, Amanda E. D. ^{[1
]}

Siegel, Marni B. ^{[1
,2
]}

Anders, Carey K. ^{[1
,3
]}

机构：

[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Dept Med, Div Hematol Oncol, Chapel Hill, NC 27599 USA

来源：

BREAST CANCER RESEARCH | 2014年 / 16卷 / 03期

关键词：

CELLS; ASTROCYTES; SURVIVAL; PROMOTE; RELAPSE;

D O I：

10.1186/bcr3651

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Brain metastases remain a significant challenge in the treatment of breast cancer patients due to the unique environment posed by the central nervous system. A better understanding of the biology of breast cancer cells that have metastasized to the brain is required to develop improved therapies. A recent Proceedings of the National Academy of Sciences article demonstrates that breast cancer cells in the brain microenvironment express gamma-aminobutyric acid (GABA)-related genes, enabling them to utilize GABA as an oncometabolite, thus gaining a proliferative advantage. In this viewpoint, we highlight these findings and their potential impact on the treatment of breast cancer brain metastases.

引用

页数：3

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