Role of Matrix Metalloproteinases in Angiogenesis and Cancer

被引：714

作者：

Quintero-Fabian, Saray ^{[1
]}

Arreola, Rodrigo ^{[2
]}

Becerril-Villanueva, Enrique ^{[3
]}

Cesar Torres-Romero, Julio ^{[4
]}

Arana-Argaez, Victor ^{[5
]}

Lara-Riegos, Julio ^{[4
]}

Alberto Ramirez-Camacho, Mario ^{[6
]}

Elizbeth Alvarez-Sanchez, Maria ^{[7
]}

机构：

[1] Mil Sch Grad Hlth, Multidisciplinary Res Lab, Mexico City, DF, Mexico

[2] Natl Inst Psychiat Ramon de la Fuente, Psychiat Genet Dept, Mexico City, DF, Mexico

[3] Natl Inst Psychiat Ramon de la Fuente, Psychoimmunol Lab, Mexico City, DF, Mexico

[4] Univ Autonoma Yucatan, Fac Quim, Biochem & Mol Genet Lab, Merida, Yucatan, Mexico

[5] Univ Autonoma Yucatan, Fac Quim, Pharmacol Lab, Merida, Yucatan, Mexico

[6] Univ Autonoma Yucatan, Fac Quim, Ctr Informac Med, Merida, Yucatan, Mexico

[7] Univ Autonoma Ciudad de Mexico, Genom Sci Grad Program, Mexico City, DF, Mexico

来源：

FRONTIERS IN ONCOLOGY | 2019年 / 9卷

关键词：

angiogenesis and cancer; immune system; metalloproteinases; MMP; MT-MMP; EPITHELIAL-MESENCHYMAL TRANSITION; ENDOTHELIAL GROWTH-FACTOR; PROMOTES TUMOR-GROWTH; NF-KAPPA-B; GASTRIC-CANCER; CELL INVASION; UP-REGULATION; MMP-9; EXPRESSION; TGF-BETA; VASCULOGENIC MIMICRY;

D O I：

10.3389/fonc.2019.01370

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

During angiogenesis, new vessels emerge from existing endothelial lined vessels to promote the degradation of the vascular basement membrane and remodel the extracellular matrix (ECM), followed by endothelial cell migration, and proliferation and the new generation of matrix components. Matrix metalloproteinases (MMPs) participate in the disruption, tumor neovascularization, and subsequent metastasis while tissue inhibitors of metalloproteinases (TIMPs) downregulate the activity of these MMPs. Then, the angiogenic response can be directly or indirectly mediated by MMPs through the modulation of the balance between pro- and anti-angiogenic factors. This review analyzes recent knowledge on MMPs and their participation in angiogenesis.

引用

页数：21

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