Effect of castration and finasteride on urinary oxalate excretion in male rats

被引：22

作者：

Fan, J ^{[1
]}

Glass, MA ^{[1
]}

Chandhoke, PS ^{[1
]}

机构：

[1] Univ Colorado, Hlth Sci Ctr, Div Urol, Urolithiasis Res Lab, Denver, CO 80262 USA

来源：

UROLOGICAL RESEARCH | 1998年 / 26卷 / 01期

关键词：

testosterone; dihydrotestosterone; finasteride; urinary oxalate;

D O I：

10.1007/s002400050026

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated the effects of castration and finasteride administration on urinary oxalate (Ox) excretion in a rat ethylene glycol (EG) model of urolithiasis. Male adult SD rats were divided into six groups. Group 1 were normal, untreated rats. The other five groups, all treated with 0.75% EG for 4 weeks; were as follows: group 2, non-castrated (intact) rats; group 3, castrated rats; group 4, castrated rats with a 4-cm testosterone implant; group 5, intact rats treated with high-dose finasteride (7.5 mg%); and group 6, intact rats treated with low-dose finasteride (0.75 mg%). Urinary Ox excretion increased 12.8-fold after 4 weeks of EG treatment (group 2 vs group 1). Both castration (group 3) and finasteride administration (groups 5 and 6) significantly decreased urinary Ox excretion compared with intact rats (group 2). We conclude that dihydrotestosterone is partially responsible for the exaggerated hyperoxaluria observed in the rat EG model of urolithiasis.

引用

页码：71 / 75

页数：5