A pH-responsive fluorescence probe and photosensitiser based on a tetraamino silicon(IV) phthalocyanine

被引：106
作者：
Jiang, Xiong-Jie [1 ,2 ]
Lo, Pui-Chi [1 ,2 ]
Yeung, Sin-Lui [2 ,3 ]
Fong, Wing-Ping [2 ,3 ]
Ng, Dennis K. P. [1 ,2 ]
机构：
[1] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Ctr Novel Funct Mol, Shatin, Hong Kong, Peoples R China
[3] Chinese Univ Hong Kong, Dept Biochem, Shatin, Hong Kong, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 18期
关键词：
PERIPHERAL CHLORO SUBSTITUTION; PHOTODYNAMIC THERAPY; IN-VITRO; PHOTOPHYSICAL PROPERTIES; TUMOR; SERIES; VIVO;
D O I：
10.1039/c000605j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel tetraamino silicon(IV) phthalocyanine has been prepared, of which the fluorescence emission and reactive oxygen species generation efficiency are greatly enhanced at lower pH in the range of ca. 5-7, making it a promising pH-controlled and tumour-selective fluorescence probe and photosensitiser for photodynamic therapy.
引用
收藏
页码：3188 / 3190
页数：3
相关论文
共 31 条
[1]   The present and future role of photodynamic therapy in cancer treatment [J].
Brown, SB ;
Brown, EA ;
Walker, I .
LANCET ONCOLOGY, 2004, 5 (08) :497-508
[2]   Current clinical and preclinical photosensitizers for use in photodynamic therapy [J].
Detty, MR ;
Gibson, SL ;
Wagner, SJ .
JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (16) :3897-3915
[3]   Photodynamic therapy for cancer [J].
Dolmans, DEJGJ ;
Fukumura, D ;
Jain, RK .
NATURE REVIEWS CANCER, 2003, 3 (05) :380-387
[4]   The pH difference between tumor and normal tissue offers a tumor specific target for the treatment of cancer [J].
Gerweck, LE .
DRUG RESISTANCE UPDATES, 2000, 3 (01) :49-50
[5]  
Hajri A, 2002, PHOTOCHEM PHOTOBIOL, V75, P140, DOI 10.1562/0031-8655(2002)075<0140:IVAIVE>2.0.CO
[6]  
2
[7]   Measuring reactive species and oxidative damage in vivo and in cell culture:: how should you do it and what do the results mean? [J].
Halliwell, B ;
Whiteman, M .
BRITISH JOURNAL OF PHARMACOLOGY, 2004, 142 (02) :231-255
[8]   Peripheral and axial substitution of phthalocyanines with solketal groups: Synthesis and in vitro evaluation for photodynamic therapy [J].
Hofman, Jan-Willem ;
van Zeeland, Femke ;
Turker, Selcan ;
Talsma, Herre ;
Lambrechts, Saskia A. G. ;
Sakharov, Dmitri V. ;
Hennink, Wim E. ;
van Nostrum, Cornelus F. .
JOURNAL OF MEDICINAL CHEMISTRY, 2007, 50 (07) :1485-1494
[9]   NIGERICIN ENHANCES MAFOSFAMIDE CYTOTOXICITY AT LOW EXTRACELLULAR PH [J].
JAHDE, E ;
GLUSENKAMP, KH ;
RAJEWSKY, MF .
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1991, 27 (06) :440-444
[10]   Recent progress in tumor pH targeting nanotechnology [J].
Lee, Eun Seong ;
Gao, Zhonggao ;
Bae, You Han .
JOURNAL OF CONTROLLED RELEASE, 2008, 132 (03) :164-170
1234