Coexistent choriocarcinoma and malignant mixed mesodermal tumor of the uterus

被引:23
作者
Nguyen, CP
Levi, AW
Montz, FJ
Bristow, RE
机构
[1] Johns Hopkins Hosp, Dept Obstet & Gynecol, Baltimore, MD 21287 USA
[2] Johns Hopkins Hosp, Dept Pathol, Baltimore, MD 21287 USA
关键词
D O I
10.1006/gyno.2000.5976
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objective. The purpose of this article is to report a case of coexisting uterine choriocarcinoma and uterine malignant mired mesodermal tumor (MMMT). The relevant literature is reviewed and possible pathogenesis discussed. Methods. The clinical course and histopathology of the case were reviewed and a Medline literature search for other cases was performed. Results. The patient's uterine tumor contained syncytiotrophoblastic and cytotrophoblastic cells that stained positively for the beta subunit of human chorionic gonadotrophin consistent with uterine choriocarcinoma. Pathology also revealed a second distinct neoplasm composed of adenocarcinoma admired with sarcoma, compatible with a uterine MMMT. The patient experienced metastatic choriocarcinoma to her lungs, lymph nodes, and brain. She suffered a complicated clinical course and died 7 months after her initial diagnosis. The literature search revealed that various gynecologic and nongynecologic carcinomas with trophoblastic differentiation have been described, but an association with uterine MMMT has not been previously reported. Conclusions. Trophoblastic differentiation and choriocarcinoma associated with gynecologic and nongynecologic tumors is rare. We document the presence of uterine MMMT coexisting with uterine choriocarcinoma that followed an aggressive clinical course and review the possible pathogenesis of this lesion. (C) 2000 Academic Press.
引用
收藏
页码:499 / 503
页数:5
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