The cutaneous side-effects of hydroxyurea

被引：24

作者：

Young, HS

Khan, ASA

Kendra, JR

Coulson, IH

机构：

[1] Burnley Gen Hosp, Dept Dermatol, Burnley BB10 2PQ, Lancs, England

[2] Burnley Gen Hosp, Dept Haematol, Burnley BB10 2PQ, Lancs, England

来源：

CLINICAL AND LABORATORY HAEMATOLOGY | 2000年 / 22卷 / 04期

关键词：

hydroxyurea; hydroxyurea dermopathy; skin malignancy; nonscarring alopecia; longitudinal melanonychia;

D O I：

10.1046/j.1365-2257.2000.00311.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The cutaneous side-effects of long-term hydroxyurea therapy are not widely known and only rarely reported. We report on a patient who developed widespread skin changes, including the recently recognized hydroxyurea dermopathy, during long-term treatment with hydroxyurea for polycythaemia rubra vera. The time course of the clinical changes suggests that they result from direct toxicity of hydroxyurea on the basal layer of the epidermis and mucosal surfaces. We aim to increase clinical awareness of this problem.

引用

收藏

页码：229 / 232

页数：4

相关论文

共 15 条

[1] Hydroxyurea-induced leg ulceration in 14 patients [J].

Best, PJ ;

Daoud, MS ;

Pittelkow, MR ;

Petitt, RM .

ANNALS OF INTERNAL MEDICINE, 1998, 128 (01) :29-32

[2] EFFECTS OF HYDROXYUREA THERAPY ON NORMAL SKIN - A CASE-REPORT [J].

BURNS, DA ;

SARKANY, I ;

GAYLARDE, P .

CLINICAL AND EXPERIMENTAL DERMATOLOGY, 1980, 5 (04) :447-449

[3] THE IN-VITRO AND IN-VIVO EFFECT OF RECOMBINANT INTERFERON ALPHA-2A ON CIRCULATING HEMATOPOIETIC PROGENITORS IN POLYCYTHEMIA-VERA [J].

CASTELLO, G ;

LERZA, R ;

CERRUTI, A ;

CAVALLINI, D ;

BOGLIOLO, G ;

PANNACCIULLI, I .

BRITISH JOURNAL OF HAEMATOLOGY, 1994, 87 (03) :621-623

[4] Hydroxyurea dermopathy: A unique lichenoid eruption complicating long-term therapy with hydroxyurea [J].

Daoud, MS ;

Gibson, LE ;

Pittelkow, MR .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1997, 36 (02) :178-182

[5]

Kelly R I, 1994, Australas J Dermatol, V35, P61, DOI 10.1111/j.1440-0960.1994.tb00897.x

[6] SKIN CHANGES SECONDARY TO HYDROXYUREA THERAPY [J].

KENNEDY, BJ ;

SMITH, LR ;

GOLTZ, RW .

ARCHIVES OF DERMATOLOGY, 1975, 111 (02) :183-187

[7] Hydroxyurea-induced dermopathy: A unique lichenoid eruption complicating long-term therapy with hydroxyurea [J].

Kirby, B ;

Rogers, S .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1998, 38 (05) :781-782

[8]

KLEM EB, 1978, J INVEST DERMATOL, V70, P27, DOI 10.1111/1523-1747.ep12543421

[9] UNUSUAL DERMATOLOGICAL TOXICITY OF LONG-TERM THERAPY WITH HYDROXYUREA IN CHRONIC MYELOGENOUS LEUKEMIA [J].

MONTEFUSCO, E ;

ALIMENA, G ;

GASTALDI, R ;

CARLESIMO, OA ;

VALESINI, G ;

MANDELLI, F .

TUMORI, 1986, 72 (03) :317-321

[10] Treatment of polycythemia vera: The use of hydroxyurea and pipobroman in 292 patients under the age of 65 years [J].

Najean, Y ;

Rain, JD .

BLOOD, 1997, 90 (09) :3370-3377