Effect of ascorbic acid on blood oxidative stress in experimental chronic arsenicosis in rodents

被引：47

作者：

Rana, Tanmoy ^{[1
]}

Bera, Asit Kumar ^{[1
]}

Das, Subhashree ^{[1
]}

Pan, Diganta ^{[1
]}

Bandyopadhyay, Subhasish ^{[1
]}

Bhattacharya, Debasis ^{[1
]}

De, Sumanta ^{[1
]}

Sikdar, Sourav ^{[1
]}

Das, Subrata Kumar ^{[1
]}

机构：

[1] Indian Vet Res Inst, Eastern Reg Stn, Kolkata 700037, India

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2010年 / 48卷 / 04期

关键词：

Arsenic; Ascorbic acid; Blood; Oxidative stress; ALPHA-TOCOPHEROL; NITRIC-OXIDE; LIPID-PEROXIDATION; ORAL-EXPOSURE; HUMAN ERYTHROCYTES; PROTEIN OXIDATION; PROTECTIVE ROLE; MECHANISM; DAMAGE; TOXICITY;

D O I：

10.1016/j.fct.2010.01.027

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Ascorbic acid is a sugar acid and an essential vital food nutrient found mainly in fruits and vegetables. The purpose of this study was to investigate the effects of ascorbic acid against arsenic induced oxidative stress in blood of rat. In rat, treatment with ascorbic acid prevented the increased serum enzymatic activity of AST, ALT, ALP, ACP and LDH. In addition, treatment with ascorbic acid prevented elevated production of LPO, PC and NO and restored the depletion of reduced SOD and CAT activities. Interestingly, ascorbic acid markedly upregulated lymphocytes relative mRNA expression of lymphocytes SOD2 gene corresponding to GAPDH, house keeping candidate gene in arsenic-treated rat, which might provide anti-oxidative activity in the blood. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1072 / 1077

页数：6

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