Combination of urinary kidney injury molecule-1 and interleukin-18 as early biomarker for the diagnosis and progressive assessment of acute kidney injury following cardiopulmonary bypass surgery: a prospective nested case-control study

被引：55
作者：
Liang, Xin-Ling [1 ,2 ]
Liu, Shuang-Xin [1 ]
Chen, Yuan-Han [1 ]
Yan, Li-Jun [1 ]
Li, Heng [3 ]
Xuan, Hui-Jie [1 ]
Liang, Yong-Zheng [1 ]
Shi, Wei [1 ]
机构：
[1] Guangdong Acad Med Sci, Guangdong Gen Hosp, Div Nephrol, Guangzhou 510080, Guangdong, Peoples R China
[2] Nanfang Med Univ, Guangzhou, Guangdong, Peoples R China
[3] Guangdong Acad Med Sci, Guangdong Gen Hosp, Div Lab Med, Guangzhou 510080, Guangdong, Peoples R China
来源：
BIOMARKERS | 2010年 / 15卷 / 04期
关键词：
Acute kidney injury; biomarker; cardiopulmonary bypass; kidney injury molecule-1 (Kim-1); interleukin-18 (IL-18); ACUTE-RENAL-FAILURE; RISK; IL-18; MARKER; KIM-1; ARF;
D O I：
10.3109/13547501003706558
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The aim of this nested case-control study was to assess the combined use of urinary kidney injury molecule (KIM)-1 and interleukin (IL)-18 for acute kidney injury (AKI) after cardiopulmonary bypass surgery (CPB). From a cohort of 122 subjects who underwent CPB, serial urinary KIM-1 and IL-18 concentrations were determined in 30 AKI and 92 non-AKI patients. An increased level of urinary KIM-1 was associated with the occurrence of AKI, whereas an increased level of IL-18 was related to progressive AKI. The combination of these two biomarkers facilitates the early diagnosis and assessment of the likely progression of AKI after CPB.
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收藏
页码：332 / 339
页数：8
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