A Comparison of Multimodality Treatment: Two or Four Courses of Paclitaxel plus Cisplatin or S-1 plus Cisplatin Followed by Surgery for Locally Advanced Gastric Cancer, a Randomized Phase II Trial (COMPASS)

被引：17

作者：

Yoshikawa, Takaki ^{[1
]}

Tsuburaya, Akira

Morita, Satoshi ^{[2
]}

Kodera, Yasuhiro ^{[3
]}

Ito, Seiji ^{[4
]}

Cho, Haruhiko

Miyashita, Yumi ^{[5
]}

Sakamoto, Junichi ^{[6
]}

机构：

[1] Kanagawa Canc Ctr, Dept Gastrointestinal Surg, Asahi Ku, Yokohama, Kanagawa 2410815, Japan

[2] Yokohama City Univ, Dept Biostat & Epidemiol, Med Ctr, Yokohama, Kanagawa 232, Japan

[3] Nagoya Univ, Dept Surg 2, Grad Sch Med, Nagoya, Aichi 4648601, Japan

[4] Aichi Canc Ctr, Dept Surg, Nagoya, Aichi 464, Japan

[5] Nonprofit Org ECRIN, Ctr Data, Nagoya, Aichi, Japan

[6] Nagoya Univ, Grad Sch Med, Young Leaders Program, Nagoya, Aichi 4648601, Japan

来源：

JAPANESE JOURNAL OF CLINICAL ONCOLOGY | 2010年 / 40卷 / 04期

关键词：

gastric cancer; Phase II; neoadjuvant chemotherapy; surgery; course; CHEMOTHERAPY;

D O I：

10.1093/jjco/hyp178

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This randomized Phase II trial compares neoadjuvant chemotherapy of two or four courses of S-1 (1 M tegafur-0.4 M gimestat-1 M ostat potassium) plus cisplatin or paclitaxel plus cisplatin by a two-by-two factorial design for patients with macroscopically resectable locally advanced gastric cancer. The primary endpoint is the 3-year overall survival. The sample size is 60-80 in a total for two hypotheses of the superiority of four courses to two courses and the superiority of paclitaxel plus cisplatin to S-1 plus cisplatin. In both arms, S-1 is strongly recommended post-operatively for at least 6 months but no adjuvant chemotherapy is permitted other than S-1 until recurrence. This trial could appraise more suitable cycles and regimen as neoadjuvant chemotherapy for gastric cancer.

引用

页码：369 / 372

页数：4

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