Indirect coupling of the 2(1,H)-pyrazinone scaffold with various (oligo)-saccharides via "click chemistry":: en route towards glycopeptidomimetics

被引：29

作者：

Ermolat'ev, D ^{[1
]}

Dehaen, W ^{[1
]}

Van der Eycken, E ^{[1
]}

机构：

[1] Univ Louvain, Dept Chem, Synth Organ Lab, B-3001 Louvain, Belgium

来源：

QSAR & COMBINATORIAL SCIENCE | 2004年 / 23卷 / 10期

关键词：

glycosyl azides; 1,2,3-triazoles; 2(1H)-pyrazinone; click chemistry; 1,3-dipolar cycloaddition;

D O I：

10.1002/qsar.200420049

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The indirect coupling via a 1,2,3-triazole ring system, of the 2(1H)-pyrazinone scaffold with various saccharides is described. A microwave-enhanced Cu(I)-catalyzed Huisgen [2 + 3] dipolar cycloaddition reaction is applied. This opens the way for the generation of an interesting new class of glycopeptidomimetics.

引用

页码：915 / 918

页数：4

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