Polycyclic N-Heterocyclic Compounds. Part 63 Improved Synthesis of 5-Amino-1,2-dihydrofuro[2,3-c]isoquinolines via Truce-Smiles Rearrangement and Subsequent Formation to Furo[2,3-c]isoquinoline

被引：25
|
作者：
Okuda, Kensuke [1 ]
Yoshida, Masahiko [2 ]
Hirota, Takashi [2 ]
Sasaki, Kenji [2 ]
机构：
[1] Gifu Pharmaceut Univ, Gifu 5011196, Japan
[2] Okayama Univ, Fac Pharmaceut Sci, Kita Ku, Okayama 7008530, Japan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2010年 / 58卷 / 03期
关键词：
Truce-Smiles rearrangement; furo[2,3-c]isoquinoline; furo[2,3-b]pyridine; heterocycle; spiro[cyclopropane-(1-4 ')-isoquinoline; DERIVATIVES; 2-(3-CYANOPROPYLTHIO)PYRIDINE-3-CARBONITRILE; NUCLEOSIDES;
D O I：
10.1248/cpb.58.363
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
An improved synthesis of 5-amino-1,2-dihydrofuro[2,3-c]isoquinoline has been achieved using a slight niodification of reaction Conditions for the Truce-Smiles rearrangement. Acid treatment of the obtained 5-amino-1,2-dihydrofuro [2,3-c]isoquinolines gave unexpected ring-opened spiro ring compounds. The previously unreported Parent compound, furo[2,3-c]isoquinoline, was also synthesized.
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页码：363 / 368
页数：6
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