Zebrafish as a model to explore cell metabolism

被引：39

作者：

Santoro, Massimo M. ^{[1
,2
]}

机构：

[1] Univ Leuven, Vesalius Res Ctr, Dept Oncol, Lab Endothelial Mol Biol, B-3000 Louvain, Belgium

[2] VIB, Vesalius Res Ctr, Lab Endothelial Mol Biol, B-3000 Louvain, Belgium

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2014年 / 25卷 / 10期

关键词：

zebrafish; metabolomics; tools; genetics; drug screening; metabolic disorders; DANIO-RERIO; TRANSGENIC ZEBRAFISH; FATTY LIVER; HYPERCHOLESTEROLEMIC ZEBRAFISH; VERTEBRATE DEVELOPMENT; LIPID-ACCUMULATION; ENERGY-METABOLISM; ADULT ZEBRAFISH; HUMAN-DISEASE; EMBRYOS;

D O I：

10.1016/j.tem.2014.06.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cell metabolism plays a key role in many essential biological processes. The recent availability of novel technologies and organisms to model cell metabolism in vivo is expanding current knowledge of cell metabolism. In this context, the zebrafish (Danio rerio) is emerging as a valuable model system to learn about the metabolic routes critical for cellular homeostasis. Here, the most recent methods and studies on cell metabolism are summarized, which support the overall value for the zebrafish model system not only to study metabolism but also metabolic disease states. It is envisioned that this small vertebrate system will help in the understanding of pathogenesis for numerous metabolic-related disorders in humans and in the identification of their therapeutic treatments.

引用

页码：546 / 554

页数：9

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