Epigenetic regulation of neurogenesis in the adult hippocampus

被引：56
作者：
Covic, M. [1 ]
Karaca, E. [1 ]
Lie, D. C. [1 ]
机构：
[1] German Ctr Environm Hlth, Helmholtz Ctr Munich, Inst Dev Genet, D-86754 Munich, Germany
来源：
HEREDITY | 2010年 / 105卷 / 01期
关键词：
adult neurogenesis; dynamic methylation; histone methylation; DNA methylation; epigenetic modifications; hippocampus; EMBRYONIC STEM-CELLS; ACTIVE DNA DEMETHYLATION; CENTRAL-NERVOUS-SYSTEM; ENHANCED SYNAPTIC PLASTICITY; NEWLY GENERATED NEURONS; GENE-EXPRESSION; PROGENITOR CELLS; DENTATE GYRUS; METHYLTRANSFERASES DNMT3A; TRANSCRIPTIONAL NETWORK;
D O I：
10.1038/hdy.2010.27
中图分类号：
Q14 [生态学（生物生态学）];
学科分类号：
071012 ; 0713 ;
摘要：
The dentate gyrus of the hippocampus is an exception to a 'neurogenesis-unfriendly' environment of the adult brain. New functional neurons generated in this region contribute to learning and mood regulation, and thus represent a unique form of neural plasticity. The rate of hippocampal neurogenesis significantly changes on physiological or pathological influences, such as physical activity, environmental enrichment, stress, and aging. We suggest that epigenetic mechanisms could be sensors of environmental changes and fine modulators of adult hippocampal neurogenesis. Here, we examine the role of DNA methylation and methylation of core histones mediated by the Polycomb and Trithorax complexes in the regulation of adult neurogenesis. Given the recent surprising discovery of dynamic and reversible DNA methylation in the hippocampus, we speculate regarding its regulation and its role in adult neurogenesis. Heredity (2010) 105, 122-134; doi:10.1038/hdy.2010.27; published online 24 March 2010
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页码：122 / 134
页数：13
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