Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer's disease

被引：200

作者：

Kitagishi, Yasuko ^{[1
]}

Nakanishi, Atsuko ^{[1
]}

Ogura, Yasunori ^{[1
]}

Matsuda, Satoru ^{[1
]}

机构：

[1] Nara Womens Univ, Dept Food Sci & Nutr, Nara 6308506, Japan

来源：

ALZHEIMERS RESEARCH & THERAPY | 2014年 / 6卷 / 03期

关键词：

GLYCOGEN-SYNTHASE KINASE-3-BETA; PROLYL ISOMERASE PIN1; TAU-PHOSPHORYLATION; AMYLOID-BETA; COGNITIVE IMPAIRMENT; MEDITERRANEAN DIET; SIGNALING PATHWAY; MAMMALIAN TARGET; CORTICAL-NEURONS; SH-SY5Y CELLS;

D O I：

10.1186/alzrt265

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Alzheimer's disease (AD) is characterized by the formation of senile plaques and neurofibrillary tangles composed of phosphorylated Tau. Several findings suggest that correcting signal dysregulation for Tau phosphorylation in AD may offer a potential therapeutic approach. The PI3K/AKT/GSK-3 beta pathway has been shown to play a pivotal role in neuroprotection, enhancing cell survival by stimulating cell proliferation and inhibiting apoptosis. This pathway appears to be crucial in AD because it promotes protein hyper-phosphorylation in Tau. Understanding those regulations may provide a better efficacy of new therapeutic approaches. In this review, we summarize advances in the involvement of the PI3K/AKT/GSK-3 beta pathways in cell signaling of neuronal cells. We also review recent studies on the features of several diets and the signaling pathway involved in AD.

引用

页数：7

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