The effect of strict volume control on cardiac biomarker and arterial stiffness in peritoneal dialysis patients

被引:8
作者
Kocyigit, Ismail [1 ]
Gungor, Ozkan [2 ]
Unal, Aydin [1 ]
Orscelik, Ozcan [3 ]
Eroglu, Eray [4 ]
Tunca, Onur [1 ]
Sipahioglu, Murat Hayri [1 ]
Tokgoz, Bulent [1 ]
Oymak, Oktay [1 ]
机构
[1] Erciyes Univ, Fac Med, Dept Nephrol, TR-38039 Kayseri, Turkey
[2] Kahramanmaras State Hosp, Kahramanmaras, Turkey
[3] Erciyes Univ, Fac Med, Dept Cardiol, TR-38039 Kayseri, Turkey
[4] Erciyes Univ, Fac Med, Dept Internal Med, TR-38039 Kayseri, Turkey
关键词
peritoneal dialysis; strict volume; hypertension; BRAIN NATRIURETIC PEPTIDE; PULSE-WAVE VELOCITY; CARDIOVASCULAR RISK; TECHNIQUE FAILURE; PROGNOSTIC VALUE; BLOOD-PRESSURE; MORTALITY; ASSOCIATION; IMPACT; HYPERTENSION;
D O I
10.5414/CN108148
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Introduction: Arterial stiffness is a risk marker for cardiovascular events in peritoneal dialysis (PD) patients. Strict volume control strategy has been shown to result in better cardiac functions and control of hypertension in these patients. The aim of the study was to identify the determinants of arterial stiffness and evaluate the changes in cardiac biomarkers in PD patients under strict volume control strategy. Methods: 58 PD patients were enrolled into this prospective observational study. Arterial stiffness determined by aortic pulse wave velocity (PWV), echocardiography, ambulatory blood pressure and NT-pro-BNP levels were measured at baseline and at first year. Results: The mean age of the patients was 46.4 +/- 14 years. 30 patients were on automated PD (APD) and 28 on continuous ambulatory PD (CAPD) group. In both groups, there were significant differences in PWV values at baseline and at the end of the study. A similar decrease was observed with NT-proBNP and PWV levels. In addition, a significant improvement was found in echocardiographic parameters in all patients. Comparison of APD and CAPD groups with respect to change in one year, showed no difference in echocardiographic findings, while the reduction in PWV, NT-proBNP and blood pressure values was higher in the CAPD group. Conclusions: In PD patients, strict volume control leads to a reduction in NT-pro-BNP levels, better control of blood pressure and significant improvements in cardiac functions and arterial stiffness.
引用
收藏
页码:238 / 246
页数:9
相关论文
共 32 条
[1]  
[Anonymous], 2003, Am J Kidney Dis, V42, P1
[2]  
Asci G, 2006, PERITON DIALYSIS INT, V26, P85
[3]   Cardiac Biomarkers and Noninvasive Predictors of Atherosclerosis in Chronic Peritoneal Dialysis Patients [J].
Caliskan, Yasar ;
Ozkok, Abdullah ;
Akagun, Tulin ;
Alpay, Nadir ;
Guz, Goksel ;
Polat, Nihat ;
Tufan, Fatih ;
Ecder, Tevfik ;
Bozfakioglu, Semra .
KIDNEY & BLOOD PRESSURE RESEARCH, 2012, 35 (05) :340-348
[4]   N-terminal Pro-B-Type Natriuretic Peptide is Associated with Arterial Stiffness Measured Using the Cardio-Ankle Vascular Index in Renal Transplant Recipients [J].
Chen, Yen-Cheng ;
Lee, Ming-Che ;
Lee, Chung-Jen ;
Ho, Guan-Jin ;
Yin, Wen-Yao ;
Chang, Yao-Jen ;
Hsu, Bang-Gee .
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 2013, 20 (07) :646-653
[5]   Prevalence of hypertension in patients on peritoneal dialysis: results of an Italian multicentre study [J].
Cocchi, R ;
Esposti, ED ;
Fabbri, A ;
Lucatello, A ;
Sturani, A ;
Quarello, F ;
Boero, R ;
Bruno, M ;
Dadone, C ;
Favazza, A ;
Scanziani, R ;
Tommasi, A ;
Giangrande, A .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 1999, 14 (06) :1536-1540
[6]   Arterial stiffness in renal patients: An update [J].
Covic, A ;
Gusbeth-Tatomir, P ;
Goldsmith, DJA .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2005, 45 (06) :965-977
[7]   Arterial wave reflections and mortality in haemodialysis patients - only relevant in elderly, cardiovascularly compromised? [J].
Covic, Adrian ;
Mardare, Nicoleta ;
Gusbeth-Tatomir, Paul ;
Prisada, Octavian ;
Sascau, Radu ;
Goldsmith, David J. A. .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2006, 21 (10) :2859-2866
[8]   Impact of mean arterial pressure on progression of arterial stiffness in peritoneal dialysis patients under strict volume control strategy [J].
Demirci, Mettem Sezis ;
Gungor, Ozkan ;
Kircelli, Fatih ;
Carrero, Juan Jesus ;
Tatar, Erhan ;
Demirci, Cenk ;
Kayikcioglu, Meral ;
Asci, Gulay ;
Toz, Huseyin ;
Ozkahya, Mehmet ;
Ok, Ercan .
CLINICAL NEPHROLOGY, 2012, 77 (02) :105-113
[9]  
García-López E, 2007, PERITON DIALYSIS INT, V27, pS205
[10]   Strong association between nutritional markers and arterial stiffness in continuous ambulatory peritoneal dialysis patients [J].
Gu, Yue ;
Cheng, Li-Tao ;
Chen, Hui-Min ;
Sun, Xiao-Yan ;
Tang, Li-Jun ;
Guo, Li-Juan ;
Axelsson, Jonas ;
Wang, Tao .
BLOOD PURIFICATION, 2008, 26 (04) :340-346