Inhibitors targeting the enzymatic activity and biological function of Pin1

被引：5
|
作者：
Zhang, YX [1 ]
机构：
[1] Max Planck Res Unit Enzymol Protein Folding, D-06120 Halle An Der Saale, Germany
来源：
MINI-REVIEWS IN ORGANIC CHEMISTRY | 2004年 / 1卷 / 04期
关键词：
Pin1; inhibitor; PPlase; substrate mimetics; combinatorial library; phosphorylation;
D O I：
10.2174/1570193043403055
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Pin1, a phospho-Ser/Thr-Pro specific PPIase.. participates in many biological processes. Recently. through designing substrate mimetics, or library screening, several classes of Pin1 inhibitors have been discovered. Some polyaromatic compounds, including juglone, as well as peptide mimetics containing both proline and phosphate, have been demonstrated to inhibit biological functions of Pin1.
引用
收藏
页码：359 / 366
页数：8
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