Peptide and protein recognition by designed molecules

被引：487
作者：
Peczuh, MW [1 ]
Hamilton, AD [1 ]
机构：
[1] Yale Univ, Dept Chem, New Haven, CT 06520 USA
来源：
CHEMICAL REVIEWS | 2000年 / 100卷 / 07期
关键词：
D O I：
10.1021/cr9900026
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
At present, there is a growing interest in understanding and manipulating protein-protein interactions due to their central importance in many biological processes. This article details current strategies for binding protein surfaces with emphasis on the use of designed molecules. Examples are given that indicate the great promise in the design of small molecules to bind protein surfaces.
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页码：2479 / 2493
页数：15
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