Ghrelin regulation of glucose metabolism

被引：50
作者：
Gray, Sarah M. [1 ]
Page, Laura C. [2 ]
Tong, Jenny [1 ,3 ]
机构：
[1] Duke Univ, Duke Mol Physiol Inst, Durham, NC 27701 USA
[2] Duke Univ, Dept Pediat, Div Endocrinol, Durham, NC 27706 USA
[3] Duke Univ, Dept Med, Div Endocrinol Metab & Nutr, Durham, NC USA
来源：
JOURNAL OF NEUROENDOCRINOLOGY | 2019年 / 31卷 / 07期
关键词：
ghrelin; glucose tolerance; insulin; insulin secretion; HORMONE SECRETAGOGUE RECEPTOR; DES-ACYL GHRELIN; STIMULATED INSULIN-SECRETION; O-ACYLTRANSFERASE GOAT; DECREASE FOOD-INTAKE; ENDOCRINE CELL-TYPE; UNACYLATED GHRELIN; BETA-CELLS; PANCREATIC-ISLETS; MESSENGER-RNA;
D O I：
10.1111/jne.12705
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Ghrelin and its receptor, the growth hormone secretagogue receptor 1a (GHSR1a), are implicated in the regulation of glucose metabolism via direct actions in the pancreatic islet, as well as peripheral insulin-sensitive tissues and the brain. Although many studies have explored the role of ghrelin in glucose tolerance and insulin secretion, a complete mechanistic understanding remains to be clarified. This review highlights the local expression and function of ghrelin and GHSR1a in pancreatic islets and how this axis may modulate insulin secretion from pancreatic beta-cells. Additionally, we discuss the effect of ghrelin on in vivo glucose metabolism in rodents and humans, as well as the metabolic circumstances under which the action of ghrelin may predominate.
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页数：11
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