Immunometabolism of regulatory T cells

被引：269

作者：

Newton, Ryan ^{[1
]}

Priyadharshini, Bhavana ^{[1
]}

Turka, Laurence A. ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Dept Surg, Ctr Transplantat Sci, Boston, MA 02114 USA

来源：

NATURE IMMUNOLOGY | 2016年 / 17卷 / 06期

基金：

美国国家卫生研究院;

关键词：

METABOLIC CHECKPOINT; IMMUNE HOMEOSTASIS; CIS-ELEMENT; MEMORY; DIFFERENTIATION; ACTIVATION; GENERATION; EXPRESSION; INDUCTION; RECEPTOR;

D O I：

10.1038/ni.3466

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The bidirectional interaction between the immune system and whole-body metabolism has been well recognized for many years. Via effects on adipocytes and hepatocytes, immune cells can modulate whole-body metabolism (in metabolic syndromes such as type 2 diabetes and obesity) and, reciprocally, host nutrition and commensal-microbiota-derived metabolites modulate immunological homeostasis. Studies demonstrating the metabolic similarities of proliferating immune cells and cancer cells have helped give birth to the new field of immunometabolism, which focuses on how the cell-intrinsic metabolic properties of lymphocytes and macrophages can themselves dictate the fate and function of the cells and eventually shape an immune response. We focus on this aspect here, particularly as it relates to regulatory T cells.

引用

页码：618 / 625

页数：8

共 86 条

[41] Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity [J].

Luo, Chong T. ;

Liao, Will ;

Dadi, Saida ;

Toure, Ahmed ;

Li, Ming O. .

NATURE, 2016, 529 (7587) :532-+

[42] The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function [J].

Macintyre, Andrew N. ;

Gerriets, Valerie A. ;

Nichols, Amanda G. ;

Michalek, Ryan D. ;

Rudolph, Michael C. ;

Deoliveira, Divino ;

Anderson, Steven M. ;

Abel, E. Dale ;

Chen, Benny J. ;

Hale, Laura P. ;

Rathmell, Jeffrey C. .

CELL METABOLISM, 2014, 20 (01) :61-72

[43]

Maloy K J., 2001, Nat Immunol

[44] An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells [J].

Mezrich, Joshua D. ;

Fechner, John H. ;

Zhang, Xiaoji ;

Johnson, Brian P. ;

Burlingham, William J. ;

Bradfield, Christopher A. .

JOURNAL OF IMMUNOLOGY, 2010, 185 (06) :3190-3198

[45] Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation [J].

Michalek, Ryan D. ;

Gerriets, Valerie A. ;

Nichols, Amanda G. ;

Inoue, Makoto ;

Kazmin, Dmitri ;

Chang, Ching-Yi ;

Dwyer, Mary A. ;

Nelson, Erik R. ;

Pollizzi, Kristen N. ;

Ilkayeva, Olga ;

Giguere, Vincent ;

Zuercher, William J. ;

Powell, Jonathan D. ;

Shinohara, Mari L. ;

McDonnell, Donald P. ;

Rathmell, Jeffrey C. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (45) :18348-18353

[46] Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets [J].

Michalek, Ryan D. ;

Gerriets, Valerie A. ;

Jacobs, Sarah R. ;

Macintyre, Andrew N. ;

MacIver, Nancie J. ;

Mason, Emily F. ;

Sullivan, Sarah A. ;

Nichols, Amanda G. ;

Rathmell, Jeffrey C. .

JOURNAL OF IMMUNOLOGY, 2011, 186 (06) :3299-3303

[47] Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation [J].

Nakaya, Mako ;

Xiao, Yichuan ;

Zhou, Xiaofei ;

Chang, Jae-Hoon ;

Chang, Mikyoung ;

Cheng, Xuhong ;

Blonska, Marzenna ;

Lin, Xin ;

Sun, Shao-Cong .

IMMUNITY, 2014, 40 (05) :692-705

[48] Suppression of T-cell lymphomagenesis in mice requires PTEN phosphatase activity [J].

Newton, Ryan H. ;

Lu, Yu ;

Papa, Antonella ;

Whitcher, Greg H. ;

Kang, Youn-Jung ;

Yan, Catherine ;

Pandolfi, Pier Paolo ;

Turka, Laurence A. .

BLOOD, 2015, 125 (05) :852-855

[49] Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development [J].

O'Sullivan, David ;

van der Windt, Gerritje J. W. ;

Huang, Stanley Ching-Cheng ;

Curtis, Jonathan D. ;

Chang, Chih-Hao ;

Buck, Michael D. ;

Qiu, Jing ;

Smith, Amber M. ;

Lam, Wing Y. ;

DiPlato, Lisa M. ;

Hsu, Fong-Fu ;

Birnbaum, Morris J. ;

Pearce, Edward J. ;

Pearce, Erika L. .

IMMUNITY, 2014, 41 (01) :75-88

[50] T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development [J].

Ohkura, Naganari ;

Hamaguchi, Masahide ;

Morikawa, Hiromasa ;

Sugimura, Kyoko ;

Tanaka, Atsushi ;

Ito, Yoshinaga ;

Osaki, Motonao ;

Tanaka, Yoshiaki ;

Yamashita, Riu ;

Nakano, Naoko ;

Huehn, Jochen ;

Fehling, Hans Joerg ;

Sparwasser, Tim ;

Nakai, Kenta ;

Sakaguchi, Shimon .

IMMUNITY, 2012, 37 (05) :785-799

← 1 2 3 4 5 6 7 8 9 →