Immunometabolism of regulatory T cells

被引：269

作者：

Newton, Ryan ^{[1
]}

Priyadharshini, Bhavana ^{[1
]}

Turka, Laurence A. ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Dept Surg, Ctr Transplantat Sci, Boston, MA 02114 USA

来源：

NATURE IMMUNOLOGY | 2016年 / 17卷 / 06期

基金：

美国国家卫生研究院;

关键词：

METABOLIC CHECKPOINT; IMMUNE HOMEOSTASIS; CIS-ELEMENT; MEMORY; DIFFERENTIATION; ACTIVATION; GENERATION; EXPRESSION; INDUCTION; RECEPTOR;

D O I：

10.1038/ni.3466

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The bidirectional interaction between the immune system and whole-body metabolism has been well recognized for many years. Via effects on adipocytes and hepatocytes, immune cells can modulate whole-body metabolism (in metabolic syndromes such as type 2 diabetes and obesity) and, reciprocally, host nutrition and commensal-microbiota-derived metabolites modulate immunological homeostasis. Studies demonstrating the metabolic similarities of proliferating immune cells and cancer cells have helped give birth to the new field of immunometabolism, which focuses on how the cell-intrinsic metabolic properties of lymphocytes and macrophages can themselves dictate the fate and function of the cells and eventually shape an immune response. We focus on this aspect here, particularly as it relates to regulatory T cells.

引用

页码：618 / 625

页数：8

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