共 42 条
MicroRNA-98 inhibits TGF-β1-induced differentiation and collagen production of cardiac fibroblasts by targeting TGFBR1
被引:38
作者:

Cheng, Ranran
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机构:
Hebei Univ Engn, Med Dept, Affiliated Hosp, Handan 056002, Hebei, Peoples R China
Hebei Univ Engn, Coll Med, Handan 056002, Hebei, Peoples R China Hebei Univ Engn, Med Dept, Affiliated Hosp, Handan 056002, Hebei, Peoples R China

Dang, Ruiying
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h-index: 0
机构:
Hebei Univ Engn, Affiliated Hosp, Emergency Dept, Congtai Rd 81, Handan 056002, Hebei, Peoples R China Hebei Univ Engn, Med Dept, Affiliated Hosp, Handan 056002, Hebei, Peoples R China

Zhou, Yan
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Hebei Univ Engn, Med Dept, Affiliated Hosp, Handan 056002, Hebei, Peoples R China
Hebei Univ Engn, Coll Med, Handan 056002, Hebei, Peoples R China Hebei Univ Engn, Med Dept, Affiliated Hosp, Handan 056002, Hebei, Peoples R China

Ding, Min
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Hebei Univ Engn, Coll Med, Handan 056002, Hebei, Peoples R China Hebei Univ Engn, Med Dept, Affiliated Hosp, Handan 056002, Hebei, Peoples R China

Hua, Huikun
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h-index: 0
机构:
Hebei Univ Engn, Coll Med, Handan 056002, Hebei, Peoples R China Hebei Univ Engn, Med Dept, Affiliated Hosp, Handan 056002, Hebei, Peoples R China
机构:
[1] Hebei Univ Engn, Med Dept, Affiliated Hosp, Handan 056002, Hebei, Peoples R China
[2] Hebei Univ Engn, Affiliated Hosp, Emergency Dept, Congtai Rd 81, Handan 056002, Hebei, Peoples R China
[3] Hebei Univ Engn, Coll Med, Handan 056002, Hebei, Peoples R China
来源:
关键词:
MicroRNA-98;
Human cardiac fibroblasts;
TGF-beta;
1;
Cardiac fibrosis;
TGFBR1;
GROWTH-FACTOR-BETA;
FIBROSIS;
ANGIOTENSIN;
PROLIFERATION;
MECHANISMS;
EXERCISE;
PATHWAY;
MIR-21;
AKT;
D O I:
10.1007/s13577-017-0163-0
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
To investigate the effects of miR-98 on TGF-beta 1-induced cardiac fibrosis in human cardiac fibroblasts (HCFs), and to establish the mechanism underlying these effects, HCFs were transfected with miR-98 inhibitor or mimic, and then treated with or without TGF-beta 1. The level of miR-98 was determined by qRT-PCR in TGF-beta 1-induced HCFs. Cell differentiation and collagen accumulation of HCFs were detected by qRT-PCR and Western blot assays, respectively. The mRNA and protein expressions of TGFBR1 were determined by qRT-PCR and Western blotting. In this study, the outcomes showed that TGF-beta 1 could dramatically decrease the level of miR-98 in a time- and concentration-dependent manner. Upregulation of miR-98 dramatically improved TGF-beta 1-induced increases in cell differentiation and collagen accumulation of HCFs. Moreover, bioinformatics analysis predicted that the TGFBR1 was a potential target gene of miR-98. Luciferase reporter assay demonstrated that miR-98 could directly target TGFBR1. Inhibition of TGFBR1 had the similar effect as miR-98 overexpression. Downregulation of TGFBR1 in HCFs transfected with miR-98 inhibitor partially reversed the protective effect of miR-98 overexpression on TGF-beta 1-induced cardiac fibrosis in HCFs. Upregulation of miR-98 ameliorates TGF-beta 1-induced differentiation and collagen accumulation of HCFs by downregulation of TGFBR1. These results provide further evidence for protective effect of miR-98 overexpression on TGF-beta 1-induced cardiac fibrosis.
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页码:192 / 200
页数:9
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