Asymptomatic conjunctival mucosa-associated lymphoid tissue-type lymphoma with presumed intraocular involvement

被引：15

作者：

Ramulu, Pradeep ^{[1
]}

Iliff, Nicholas T. ^{[1
]}

Green, W. Richard ^{[1
]}

Kuo, Irene C. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Wilmer Eye Inst, Baltimore, MD 21236 USA

来源：

CORNEA | 2007年 / 26卷 / 04期

关键词：

conjunctiva; lymphoma; lymphoid hyperplasia; mucosa-associated; lymphoid tissue;

D O I：

10.1097/ICO.0b013e3180307667

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To report a case of conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma with presumed intraocular involvement. Methods: Observational case report. Results: A 73-year-old white man presented for a routine eye examination and was found to have a salmon-colored bulbar conjunctival mass of the left eye. Ultrasound showed a low-reflective mass with diffuse thickening of the ciliary body and choroid. Immunohistochemistry and flow cytometry of an incisional biopsy specimen suggested a polyclonal lesion. Treatment with topical steroids yielded no clinical improvement, and excisional biopsy was performed. A diagnosis of MALT lymphoma was made after polymerase chain reaction (PCR) analysis of the immunoglobulin heavy chain (IgH) locus revealed a clonal B-cell population. Conclusions: Conjunctival MALT lymphoma can present without symptoms and can extend intraocularly. PCR analysis of the IgH locus can identify lesion clonality when immunohistochemistry and flow cytometry fail to do so.

引用

页码：484 / 486

页数：3

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