Reproducibility across microwave instruments:: First example of genuine parallel scale up of compounds under microwave irradiation

One of the major issues associated to microwave assisted organic chemistry is reproducibility. In the present article we demonstrate that reproducibility of results can be obtained from commercially available single-mode and multimode microwave reactors. In order to make an appropriate comparison of results obtained in both systems, alkylation reactions were used as a model. Based on the reproducibility observed in these experiments, parallel scale up of compounds in one irradiation experiment is reported for the first time.