Phytochemical mediated gold nanoparticles and their PTP 1B inhibitory activity

被引：49

作者：

Basha, Sabjan Khaleel ^{[1
]}

Govindaraju, Kasivelu ^{[1
]}

Manikandan, Ramar ^{[2
]}

Ahn, Jong Seog ^{[3
]}

Bae, Eun Young ^{[3
]}

Singaravelu, Ganesan ^{[1
]}

机构：

[1] Thiruvalluvar Univ, Dept Zool, Vellore 632004, Tamil Nadu, India

[2] Alagappa Univ, Ctr Anim Hlth & Management, Karaikkudi 630003, Tamil Nadu, India

[3] Korea Res Inst Biosci & Biotechnol, Funct Metabolite Res Ctr, Taejon 305806, South Korea

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2010年 / 75卷 / 02期

关键词：

Guavanoic acid; Gold nanoparticles; Biological synthesis; PTP; 1B; TYROSINE-PHOSPHATASE; 1B; PSIDIUM-GUA[!text type='JAVA']JAVA[!/text; ANTIMICROBIAL ACTIVITIES; BIOLOGICAL SYNTHESIS; IN-VITRO; EXTRACTS; SILVER; CELLS;

D O I：

10.1016/j.colsurfb.2009.09.008

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Current discovery demonstrates the rapid formation of gold nanoparticles with guavanoic acid a phytochemical of Psidium guajava (Pg). The pharmacological capabilities of the phytochemicals present in the leaves of Pg and their ability to generate gold nanoparticles is presented herein. The new genre of green nanoparticles exhibit remarkable Protein Tyrosine Phosphatase 1B (PTP 1B) inhibitory activity and in vitro stability in various physiological medium including saline, histidine, cysteine, bovine serum albumin (BSA), human serum albumin (HSA) and buffers (pH 5, 7 and 9). It is predicted that this new technology will be felt greatly in several routes of pharmaceuticals. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：405 / 409

页数：5

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