Regulation of virulence factors in Pseudomonas aeruginosa

被引：0

作者：

Lazdunski, A ^{[1
]}

机构：

[1] CNRS, Inst Biol Struct & Microbiol, Lab Ingn Syst Macromol, F-13402 Marseille 20, France

来源：

MEDECINE ET MALADIES INFECTIEUSES | 1998年 / 28卷

关键词：

Pseudomonas; response regulator; quorum sensing;

D O I：

暂无

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Pseudomonas aeruginosa is an opportunistic pathogen responsible for numerous nosocomial infections. A wide variety of extracellular enzymes and toxins contribute to the virulence of this bacterium. Most of these virulence factors are not synthesized constitutively and are very often produced in response to multiple environmental stimuli. This adaptation is frequently mediated by two-component regulatory systems. Furthermore, the production of many virulence factors and secondary metabolites is regulated in correlation with cell density through so-called quorum sensing.

引用

页码：109 / 118

页数：10

共 40 条

[1] NUCLEOTIDE-SEQUENCE OF THE PSEUDOMONAS-AERUGINOSA PHOB GENE, THE REGULATORY GENE FOR THE PHOSPHATE REGULON [J].

ANBA, J ;

BIDAUD, M ;

VASIL, ML ;

LAZDUNSKI, A .

JOURNAL OF BACTERIOLOGY, 1990, 172 (08) :4685-4689

[2] PSEUDOMONAS-AERUGINOSA EXOENZYME-S IS AN ADHESIN [J].

BAKER, NR ;

MINOR, V ;

DEAL, C ;

SHAHRABADI, MS ;

SIMPSON, DA ;

WOODS, DE .

INFECTION AND IMMUNITY, 1991, 59 (09) :2859-2863

[3] PRODUCTION OF THE PSEUDOMONAS-AERUGINOSA NEURAMINIDASE IS INCREASED UNDER HYPEROSMOLAR CONDITIONS AND IS REGULATED BY GENES INVOLVED IN ALGINATE EXPRESSION [J].

CACALANO, G ;

KAYS, M ;

SAIMAN, L ;

PRINCE, A .

JOURNAL OF CLINICAL INVESTIGATION, 1992, 89 (06) :1866-1874

[4] Regulation of the xcp secretion pathway by multiple quorum-sensing modulons in Pseudomonas aeruginosa [J].

ChaponHerve, V ;

Akrim, M ;

Latifi, A ;

Williams, P ;

Lazdunski, A ;

Bally, M .

MOLECULAR MICROBIOLOGY, 1997, 24 (06) :1169-1178

[5]

CHI E, 1991, INFECT IMMUN, V178, P5361

[6] PfeR, an enterobactin-responsive activator of ferric enterobactin receptor gene expression in Pseudomonas aeruginosa [J].

Dean, CR ;

Neshat, S ;

Poole, K .

JOURNAL OF BACTERIOLOGY, 1996, 178 (18) :5361-5369

[7] SEQUENCE OF A CLUSTER OF GENES-CONTROLLING SYNTHESIS AND SECRETION OF ALKALINE PROTEASE IN PSEUDOMONAS-AERUGINOSA - RELATIONSHIPS TO OTHER SECRETORY PATHWAYS [J].

DUONG, F ;

LAZDUNSKI, A ;

CAMI, B ;

MURGIER, M .

GENE, 1992, 121 (01) :47-54

[8] PROTEIN SECRETION IN GRAM-NEGATIVE BACTERIA - TRANSPORT ACROSS THE OUTER-MEMBRANE INVOLVES COMMON MECHANISMS IN DIFFERENT BACTERIA [J].

FILLOUX, A ;

BALLY, M ;

BALL, G ;

AKRIM, M ;

TOMMASSEN, J ;

LAZDUNSKI, A .

EMBO JOURNAL, 1990, 9 (13) :4323-4329

[9] ExoU expression by Pseudomonas aeruginosa correlates with acute cytotoxicity and epithelial injury [J].

FinckBarbancon, V ;

Goranson, J ;

Zhu, L ;

Sawa, T ;

WienerKronish, JP ;

Fleiszig, SMJ ;

Wu, C ;

MendeMueller, L ;

Frank, DW .

MOLECULAR MICROBIOLOGY, 1997, 25 (03) :547-557

[10] Intracellular targeting of exoenzyme S of Pseudomonas aeruginosa via type III-dependent translocation induces phagocytosis resistance, cytotoxicity and disruption of actin microfilaments [J].

FrithzLindsten, E ;

Du, YD ;

Rosqvist, R ;

Forsberg, A .

MOLECULAR MICROBIOLOGY, 1997, 25 (06) :1125-1139

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