STRUCTURE-ACTIVITY RELATIONSHIPS OF SYNTHESIZED PROCYANIDIN OLIGOMERS: DPPH RADICAL SCAVENGING ACTIVITY AND MAILLARD REACTION INHIBITORY ACTIVITY

被引：5
作者：
Saito, Akiko [1 ]
Nakajima, Noriyuki [1 ,2 ]
机构：
[1] Toyama Prefectural Univ, Biotechnol Res Ctr, Toyama 9390398, Japan
[2] Toyama Prefectural Univ, Fac Engn, Dept Biotechnol, Toyama 9390398, Japan
来源：
HETEROCYCLES | 2010年 / 80卷 / 02期
基金：
日本学术振兴会;
关键词：
Condensed Tannin; Antioxidant; Tea Catechin; Polyphenol; Artificial Procyanidin Oligomer; HIGHLY STEREOSELECTIVE-SYNTHESIS; EQUIMOLAR CONDENSATION; CATECHIN CONDENSATION; ANTIOXIDANT ACTIVITY; SYSTEMATIC SYNTHESIS; EFFICIENT SYNTHESIS; 3,4-TRANS CATECHIN; PROANTHOCYANIDINS; FLAVONOIDS; GLYCATION;
D O I：
10.3987/COM-09-S(S)88
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Procyanidins are known as condensed tannins and/or oligomeric flavonoids, and are present in many edible plants and show interesting various biological activities. We previously developed and reported a simple and versatile method of synthesizing procyanidin oligomers consisting of (-)-epicatechin and (+)-catechin. Here, we report the structure activity relationships (SAR) between the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity and Mail lard reaction inhibitory activities of various procyanidin oligomers synthesized, including dimers, trimers, tetramers, pentamers, 3-O-substituted oligomers, and other artificial oligomers.
引用
收藏
页码：1081 / 1090
页数：10
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