Fertility preservation in the pediatric cancer patient

被引：5

作者：

Yu, Richard N. ^{[1
]}

机构：

[1] Boston Childrens Hosp, Dept Urol, 300 Longwood Ave, Boston, MA 02115 USA

来源：

CURRENT OPINION IN UROLOGY | 2019年 / 29卷 / 05期

关键词：

fertility preservation; pediatric cancer; sperm; spermatogonial stem cells; STEM-CELL TRANSPLANTATION; AMERICAN-SOCIETY; TESTIS; COHORT; SPERM;

D O I：

10.1097/MOU.0000000000000655

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of review Long-term survival rates from childhood cancers approach 85% with many of these patients now reaching adulthood and facing the consequences of prior cancer treatment including infertility. This highlights the importance of discussing fertility risk and presenting fertility preservation options prior to initiation of cancer treatment. This article reviews the current literature on fertility preservation in adolescents, young adults, and prepubertal patients. Recent findings Sperm banking remains the gold standard for fertility preservation in adolescents and young adults. Testicular sperm extraction and electroejaculation may also be utilized in patients that are unable to produce a semen sample. Fertility preservation options for prepubertal patients remain experimental but recent data illustrate the potential to restore spermatogenesis using spermatogonial stem cells. Fertility risk and fertility preservation options for pediatric patients should be routinely discussed at the time of cancer diagnosis. Sperm preservation should be routinely offered to adolescents and young adults at risk for infertility from cancer treatment. Preservation of prepubertal spermatogonial stem cells can be offered as an experimental option.

引用

页码：477 / 480

页数：4

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