Evidence of Intact Histatins in the in vivo Acquired Enamel Pellicle

被引：66

作者：

Siqueira, W. L. ^{[2
]}

Margolis, H. C. ^{[3
]}

Helmerhorst, E. J. ^{[1
]}

Mendes, F. M. ^{[4
]}

Oppenheim, F. G. ^{[1
]}

机构：

[1] Boston Univ, Henry M Goldman Sch Dent Med, Dept Periodontol & Oral Biol, CABR, Boston, MA 02118 USA

[2] Univ Western Ontario, Dept Biochem, Schulich Sch Med & Dent, London, ON, Canada

[3] Forsyth Inst, Dept Biomineralizat, Boston, MA USA

[4] Univ Sao Paulo, Fac Dent, Dept Pediat Dent, BR-05508 Sao Paulo, Brazil

来源：

JOURNAL OF DENTAL RESEARCH | 2010年 / 89卷 / 06期

关键词：

histatin; proteomics; enamel pellicle; demineralization; saliva; HISTIDINE-RICH POLYPEPTIDE; HUMAN-PAROTID SECRETION; MASS-SPECTROMETRY; CANDIDA-ALBICANS; PROTEINS; DEMINERALIZATION; HYDROXYAPATITE; IDENTIFICATION; ADSORPTION; PROTEOME;

D O I：

10.1177/0022034510363384

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Understanding the composition and function of the acquired enamel pellicle (AEP) has been a major goal in oral biology. The aim of this study was to test the hypothesis that intact histatins are part of the in vivo AEP and that histatins after adsorption to HA have effects on in vitro enamel demineralization. This is the first study demonstrating the presence of intact histatins in vivo in the AEP. The in vitro experiments show that all naturally occurring histatins in the AEP have the potential to provide some level of protection against acid injury.

引用

页码：626 / 630

页数：5

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