Copper-catalyzed radical cascade cyclization of 2-(allyloxy) arylaldehydes towards chroman-4-one derivatives

被引：3

作者：

Guo, Wenbin ^{[1
]}

Gui, Linlin ^{[1
]}

Chen, Xin ^{[1
]}

Dai, Zhijun ^{[3
]}

Wang, Liping ^{[1
]}

Wang, Xiaoji ^{[1
,2
]}

机构：

[1] Jiangxi Sci & Technol Normal Univ, Sch Life Sci, Nanchang 330013, Jiangxi, Peoples R China

[2] Dongguan Univ Technol, Sch Chem Engn & Energy Technol, Dongguan 523830, Peoples R China

[3] Anyang Normal Univ, Coll Chem & Chem Engn, Anyang 455000, Peoples R China

来源：

TETRAHEDRON LETTERS | 2022年 / 94卷

关键词：

Difluoroacetylation; Chroman-4-one; Copper-catalyzed; Radical; FUNCTIONALIZED CHROMAN-4-ONES; BIOLOGICAL EVALUATION; CARBOXYLIC-ACIDS; FLUORINE; DIFLUOROACETYLATION; ALDEHYDES; ACCESS;

D O I：

10.1016/j.tetlet.2021.153605

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper catalyzed difluoroacetylation of 2-(allyloxy)arylaldehydes was disclosed. In the present transformation, various 2-(allyloxy)arylaldehydes and difluoro reagents were performed smoothly, and a serises of chroman-4-one derivatives were generated in moderate to good yields via radical cascade cyclization. This protocol could promise a practical and efficient synthetic method for pharmaceutically interesting chroman-4-ones.(c) 2021 Elsevier Ltd. All rights reserved.

引用

页数：6

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