Enzyme-responsive polymer hydrogel particles for controlled release

被引：234
作者：
Thornton, Paul D.
Mart, Robert J.
Ulijn, Rein V.
机构：
[1] Sch Mat, Manchester M1 7HS, Lancs, England
[2] MIB, Manchester M1 7HS, Lancs, England
来源：
ADVANCED MATERIALS | 2007年 / 19卷 / 09期
基金：
英国工程与自然科学研究理事会;
关键词：
D O I：
10.1002/adma.200601784
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A conceptually new approach to polymer-based enzyme-triggered release is described, whereby the selective catalytic action of (disease-specific) enzymes triggers a charge-induced swelling response in chemically crosslinked hydrogel particles, resulting in the release of physically entrapped macromolecules (see figure).
引用
收藏
页码：1252 / +
页数：6
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