Synthesis of highly functionalized piperidines by one-pot multicomponent reaction using tetrabutylammonium tribromide (TBATB)

被引：157
|
作者：
Khan, Abu T. [1 ]
Lal, Mohan [1 ]
Khan, Md Musawwer [1 ]
机构：
[1] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, India
来源：
TETRAHEDRON LETTERS | 2010年 / 51卷 / 33期
关键词：
TBATB; Heterocycles; Piperidines; Multicomponent reactions; 1,3-Dicarbonyl compounds; EFFICIENT CHEMOSELECTIVE REAGENT; ENVIRONMENTALLY BENIGN SYNTHESIS; DIELS-ALDER REACTION; CYCLIZATION REACTIONS; CARBONYL-COMPOUNDS; CONCISE SYNTHESIS; DERIVATIVES; EXPEDIENT; ATOM; INHIBITORS;
D O I：
10.1016/j.tetlet.2010.06.069
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Tetrabutylammonium tribromide (TBATB) has been found to be an efficient catalyst for the one-pot synthesis of highly substituted piperidines through a combination of 1,3-dicarbonyl compounds, aromatic aldehydes, and various amines in ethanol at room temperature Atom economy. good yields, environmentally benign. and mild reaction conditions are some of the important features of this protocol (C) 2010 Elsevier Ltd All rights reserved
引用
收藏
页码：4419 / 4424
页数：6
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