Automated analysis of confocal laser endomicroscopy images to detect head and neck cancer

被引：30
作者：
Dittberner, Andreas [1 ,5 ]
Rodner, Erik [2 ]
Ortmann, Wolfgang [2 ]
Stadler, Joachim [1 ,6 ]
Schmidt, Carsten [3 ]
Petersen, Iver [4 ]
Stallmach, Andreas [3 ]
Denzler, Joachim [2 ]
Guntinas-Lichius, Orlando [1 ]
机构：
[1] Jena Univ Hosp, Dept Otorhinolaryngol, Lessingstr 2, D-07740 Jena, Germany
[2] Univ Jena, Dept Comp Sci, Jena, Germany
[3] Jena Univ Hosp, Dept Internal Med 4, Div Gastroenterol Hepatol & Infect Dis, D-07740 Jena, Germany
[4] Jena Univ Hosp, Inst Pathol, D-07740 Jena, Germany
[5] Univ Erlangen Nurnberg, Dept Otorhinolaryngol Head & Neck Surg, D-91054 Erlangen, Germany
[6] Heinrich Braun Klinikum, Dept Otorhinolaryngol, Zwickau, Germany
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2016年 / 38卷
关键词：
head and neck cancer; diagnostics; confocal microscopy; segmentation; image analysis; OPTICAL COHERENCE TOMOGRAPHY; BASAL-CELL CARCINOMA; ORAL NEOPLASIA; DIAGNOSIS; MICROSCOPY; SURGERY; MUCOSA;
D O I：
10.1002/hed.24253
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Background. The purpose of this study was to develop an automated image analysis algorithm to discriminate between head and neck cancer and nonneoplastic epithelium in confocal laser endomicroscopy (CLE) images. Methods. CLE was applied to image head and neck cancer epithelium in vivo. Histopathologic diagnosis from biopsies was used to classify the CLE images offline as cancer or noncancer tissue. The classified images were used to train automated software based on distance map histograms. The performance of the final algorithm was confirmed by "leave 2 patients out" cross-validation and area under the curve (AUC)/receiver operating characteristic (ROC) analysis. Results. Ninety-two CLE videos and 92 biopsies were analyzed from 12 patients. One hundred two frames of classified neoplastic tissue and 52 frames of nonneoplastic tissue were used for cross-validation of the developed algorithm. AUC varied from 0.52 to 0.92. Conclusion. The proposed software allows an objective classification of CLE images of head and neck cancer and adjacent nonneoplastic epithelium. (C) 2015 Wiley Periodicals, Inc.
引用
收藏
页码：E1419 / E1426
页数：8
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