Choosing the Right Coupling Reagent for Peptides: A Twenty-Five-Year Journey

被引：136

作者：

Albericio, Fernando ^{[1
,2
,3
,4
]}

El-Faham, Ayman ^{[2
,5
]}

机构：

[1] Univ KwaZulu Natal, Sch Chem & Phys, Univ Rd, ZA-4001 Durban, South Africa

[2] King Saud Univ, Dept Chem, Coll Sci, POB 2455, Riyadh 11451, Saudi Arabia

[3] Univ Barcelona, Dept Organ Chem, Marti i Franques 1-11, E-08028 Barcelona, Spain

[4] CIBER BBN, Networking Ctr Bioengn Biomat & Nanomed, Barcelona Sci Pk,Baldiri Reixac 10, Barcelona 08028, Spain

[5] Alexandria Univ, Dept Chem, Fac Sci, POB 426, Alexandria 21321, Egypt

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2018年 / 22卷 / 07期

基金：

新加坡国家研究基金会;

关键词：

amide; aminium salts; OxymaPure; racemization; solid-phase peptide synthesis; uronium/phosphonium salts; AMINO-ACID FLUORIDES; AMIDE BOND FORMATION; SOLID-PHASE SYNTHESIS; FMOC; OXYMA; EFFICIENT; COMU; THERAPEUTICS; RACEMIZATION; HEXAFLUOROPHOSPHATE;

D O I：

10.1021/acs.oprd.8b00159

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

This work is not a typical review that is trying to cover all coupling reagents in-depth. This is a personal account-it is written in the first person-seeking to summarize the 25 years of collaboration that has brought the release of several products onto the market, together with strategies for the efficient synthesis of peptides and also other molecules of biological interest, broadly adopted by the scientific community.

引用

页码：760 / 772

页数：13

共 124 条

[1]

Abdelmoty Iman, 1994, Letters in Peptide Science, V1, P57, DOI 10.1007/BF00126274

[2] Solid-phase peptide synthesis using acetonitrile as a solvent in combination with PEG-based resins [J].