A Brief Overview of Escherichia coli O157:H7 and Its Plasmid O157
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作者:
Lim, Ji Youn
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Univ Idaho, Dept Microbiol Mol Biol & Biochem, Moscow, ID 83844 USAUniv Idaho, Dept Microbiol Mol Biol & Biochem, Moscow, ID 83844 USA
Lim, Ji Youn
[1
]
Yoon, Jang W.
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Konkuk Univ, Sch Med, Adv Human Resource & Res Grp Med Sci BK21, Seoul 143701, South KoreaUniv Idaho, Dept Microbiol Mol Biol & Biochem, Moscow, ID 83844 USA
Yoon, Jang W.
[2
]
Hovde, Carolyn J.
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Univ Idaho, Dept Microbiol Mol Biol & Biochem, Moscow, ID 83844 USAUniv Idaho, Dept Microbiol Mol Biol & Biochem, Moscow, ID 83844 USA
Hovde, Carolyn J.
[1
]
机构:
[1] Univ Idaho, Dept Microbiol Mol Biol & Biochem, Moscow, ID 83844 USA
[2] Konkuk Univ, Sch Med, Adv Human Resource & Res Grp Med Sci BK21, Seoul 143701, South Korea
Enterohemorrhagic Escherichia coli O157:H7 is a major foodborne pathogen causing severe disease in humans worldwide. Healthy cattle are a reservoir of E. coli O157:H7, and bovine food products and fresh produce contaminated with bovine waste are the most common sources for disease outbreaks in the United States. E. coli O157:H7 also survives well in the environment. The abilities to cause human disease, colonize the bovine gastrointestinal tract, and survive in the environment require that E. coli O157:H7 adapt to a wide variety of conditions. Three major virulence factors of E. coli O157:H7 have been identified including Shiga toxins, products of the pathogenicity island called the locus of enterocyte effacement, and products of the F-like plasmid pO157. Among these virulence factors, the role of pO157 is least understood. This review provides a board overview of E. coli O157:H7 with an emphasis on pO157.