A Brief Overview of Escherichia coli O157:H7 and Its Plasmid O157

被引:361
作者
Lim, Ji Youn [1 ]
Yoon, Jang W. [2 ]
Hovde, Carolyn J. [1 ]
机构
[1] Univ Idaho, Dept Microbiol Mol Biol & Biochem, Moscow, ID 83844 USA
[2] Konkuk Univ, Sch Med, Adv Human Resource & Res Grp Med Sci BK21, Seoul 143701, South Korea
基金
美国国家卫生研究院;
关键词
E. coli O157:H7; pO157; MYRISTOYL TRANSFERASE-ACTIVITY; HEMOLYTIC-UREMIC SYNDROME; INTESTINAL COLONIZATION; ENTEROCYTE EFFACEMENT; VIRULENCE FACTORS; PATHOGENICITY ISLAND; SERINE-PROTEASE; UNITED-STATES; SHIGA TOXIN; ECF OPERON;
D O I
10.4014/jmb.0908.08007
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Enterohemorrhagic Escherichia coli O157:H7 is a major foodborne pathogen causing severe disease in humans worldwide. Healthy cattle are a reservoir of E. coli O157:H7, and bovine food products and fresh produce contaminated with bovine waste are the most common sources for disease outbreaks in the United States. E. coli O157:H7 also survives well in the environment. The abilities to cause human disease, colonize the bovine gastrointestinal tract, and survive in the environment require that E. coli O157:H7 adapt to a wide variety of conditions. Three major virulence factors of E. coli O157:H7 have been identified including Shiga toxins, products of the pathogenicity island called the locus of enterocyte effacement, and products of the F-like plasmid pO157. Among these virulence factors, the role of pO157 is least understood. This review provides a board overview of E. coli O157:H7 with an emphasis on pO157.
引用
收藏
页码:5 / 14
页数:10
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