Histone deacetylases and cancer

被引：809

作者：

Glozak, M. A. ^{[1
]}

Seto, E. ^{[1
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA

来源：

ONCOGENE | 2007年 / 26卷 / 37期

基金：

美国国家卫生研究院;

关键词：

acetylation; deacetylation; cancer; HDAC; HDAC inhibitors;

D O I：

10.1038/sj.onc.1210610

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Histone deacetylases ( HDACs) regulate the expression and activity of numerous proteins involved in both cancer initiation and cancer progression. By removal of acetyl groups from histones, HDACs create a non-permissive chromatin conformation that prevents the transcription of genes that encode proteins involved in tumorigenesis. In addition to histones, HDACs bind to and deacetylate a variety of other protein targets including transcription factors and other abundant cellular proteins implicated in control of cell growth, differentiation and apoptosis. This review provides a comprehensive examination of the transcriptional and post-translational mechanisms by which HDACs alter the expression and function of cancer-associated proteins and examines the general impact of HDAC activity in cancer.

引用

页码：5420 / 5432

页数：13

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